Reaction profile

The FDA adverse-event record for hypocalcaemia

481 FDA reports name hypocalcaemia, a high-volume reaction in the CVM extract (VeDDRA 2685). Plate stamps and neighbourhood peers follow.

#655 of 2,481
by report volume (all reactions)
481
reports citing this reaction
39.9%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Hypocalcaemia has 481 reports now versus 438 in that prior snapshot: 43 more (9.8%).

Report change
+43
Death-coded reports
+12
Death-coded share
−1.2 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Hypocalcaemia changes

FDA AER · VeDDRA plate

Code 2685 VOL-LOW

VOL-LOW · DEATH-HOT · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 481 reports
  • DEATH-HOT 39.9%
  • MID-PACK #655/2481
  • PHOTO-FINISH Respiratory signs
  • SPECIES-DOG Dog · 313
  • DRUG-LEAD Maropitant Citrate · 106
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Respiratory signs (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Hypocalcaemia

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Hypocalcaemia · this reaction481Respiratory signs · near481Proprioception abnorm… · near480Abdominal effusion · near478Oral cavity disorder… · near478Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Hypocalcaemia

Hypocalcaemia: high death-coded share in the FDA AER plate

Signature read: 192 death-coded reports is a heavy tail count for Hypocalcaemia in the CVM extract. Report volume is upper-third scale: 481 named reports in the openFDA extract. Death-coded share is upper-third: 192 of 481 reports (39.9% of named reports). Nearest volume peer: Respiratory signs (±0 reports). Lead species Dog (313). Lead co-reported drug Maropitant Citrate (106).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 313
Cat 143
Horse 22
Cattle 2
Other Birds 1

Breeds Most Affected

Domestic Shorthair 104
Retriever - Labrador 36
Terrier - Yorkshire 25
Crossbred Canine/dog 23
Chihuahua 19
Maltese 12
Quarter Horse 11
Retriever - Golden 10
Domestic Mediumhair 10
Shepherd Dog - Australian 10

Associated Drugs

Maropitant Citrate 106
Gabapentin 44
Carprofen 41
Buprenorphine 31
Oclacitinib Maleate 30
Prednisone 29
Moxidectin 29
Bedinvetmab 28
Meloxicam 24
Metronidazole 23
Butorphanol 23
Midazolam 22
Fluralaner 13.64% 12-Week Chew 21
Enrofloxacin 20
Isoflurane 20
Cefovecin 19
Famotidine 19
Rabies Vaccine 18
Bexagliflozin 18
Trilostane 17

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Hypocalcaemia, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (481 here).

Similar death-coded share

Nearest other reactions by death-coded share (39.9% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Hypocalcaemia (#655 of 2,481 by report volume); death-coded 39.9%. PlainBreed reaction plate · death-coded report count stamp 192 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →