Reaction profile

The FDA adverse-event record for hypocalcaemia

395 FDA adverse-event reports reference hypocalcaemia (VeDDRA 2685). See the species, breeds, and drugs most associated with it below.

395
reports citing this reaction
40.5%
death-coded share
Dog
most-affected species
Maropitant Citrate
most-associated drug
Verify with FDA CVM →
395
Total Reports
160
Deaths
40.5%
Death Rate

Species Most Affected

Dog 262
Cat 111
Horse 19
Cattle 2
Other Birds 1

Breeds Most Affected

Domestic Shorthair 81
Retriever - Labrador 34
Terrier - Yorkshire 22
Crossbred Canine/dog 20
Chihuahua 18
Retriever - Golden 9
Quarter Horse 9
Pit Bull 8
Maltese 8
Domestic Mediumhair 8

Associated Drugs

Maropitant Citrate 74
Carprofen 34
Gabapentin 32
Buprenorphine 28
Moxidectin 25
Prednisone 24
Oclacitinib Maleate 24
Bedinvetmab 22
Butorphanol 21
Meloxicam 18
Isoflurane 18
Fluralaner 13.64% 12-Week Chew 18
Midazolam 18
Enrofloxacin 17
Metronidazole 16
Famotidine 16
Bexagliflozin 16
Trilostane 15
Robenacoxib 15
Maropitant 14

Hypocalcaemia Reaction Insights

395 reports name Hypocalcaemia; 160 recorded a death outcome (40.5% of reported events, not a population-level mortality rate). VeDDRA code: 2685.

By species: Dog (262 reports), Cat (111 reports), Horse (19 reports). By breed: Domestic Shorthair (81), Retriever - Labrador (34), Terrier - Yorkshire (22).

Most co-reported drugs: Maropitant Citrate (74 reports), Carprofen (34 reports), Gabapentin (32 reports), Buprenorphine (28 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.