Reaction profile

The FDA adverse-event record for hyposensitivity to pain

59 FDA reports name hyposensitivity to pain, a lower-volume reaction in the CVM extract (VeDDRA 1968). Plate stamps and neighbourhood peers follow.

#1658 of 2,481
by report volume (all reactions)
59
reports citing this reaction
45.8%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Hyposensitivity to pain has 59 reports now versus 59 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Hyposensitivity to pain changes

FDA AER · VeDDRA plate

Code 1968 VOL-LOW

VOL-LOW · DEATH-HOT · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 59 reports
  • DEATH-HOT 45.8%
  • MID-PACK #1658/2481
  • PHOTO-FINISH Hypoaesthesia
  • SPECIES-DOG Dog · 47
  • DRUG-LEAD Bedinvetmab · 21
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Hypoaesthesia (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Lower-volume neighbourhood around Hyposensitivity to pain

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Hypoaesthesia · near59Hyposensitivity to pa… · thi…59Injection site fibros… · near59Loss of smell · near59Low free thyroxine (F… · near59Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Hyposensitivity to pain

Hyposensitivity to pain: high death-coded share in the FDA AER plate

Signature read: Hyposensitivity to pain's 45.8% death-coded share is among the highest in the openFDA reaction corpus. Report volume is lower-third scale: 59 named reports in the openFDA extract. Death-coded share is upper-third: 27 of 59 reports (45.8% of named reports). Nearest volume peer: Hypoaesthesia (±0 reports). Lead species Dog (47). Lead co-reported drug Bedinvetmab (21).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 47
Cat 11
Human 1

Breeds Most Affected

Domestic Shorthair 9
Retriever - Labrador 5
Dog (unknown) 5
Crossbred Canine/dog 4
Collie - Border 4
Retriever - Golden 4
Shepherd Dog - Australian 2
Shepherd Dog - German 2
Terrier - Bull - Staffordshire 2
Terrier - Bull - American Pit 2

Associated Drugs

Bedinvetmab 21
Milbemycin Oxime + Spinosad 7
Gabapentin 7
Carprofen 5
Maropitant Citrate 4
Buprenorphine 3
Robenacoxib 3
Emodepside + Praziquantel 2
Subcutaneous Fluids 2
Moxidectin 2
Fluralaner Chew Tablets 2
Meloxicam 2
Diphenhydramine Hcl 2
Afoxolaner 2
Cefovecin 2
Melarsomine Dihydrochloride 2
Galliprant 2
Vetprofen 2
Grapiprant 2
Cefovecin Sodium 2

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Hyposensitivity to pain, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (59 here).

Similar death-coded share

Nearest other reactions by death-coded share (45.8% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Hyposensitivity to pain (#1658 of 2,481 by report volume); death-coded 45.8%. PlainBreed reaction plate · death-coded share stamp 45.8% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →