Reaction profile

The FDA adverse-event record for hyposensitivity to pain

53 FDA adverse-event reports reference hyposensitivity to pain (VeDDRA 1968). See the species, breeds, and drugs most associated with it below.

53
reports citing this reaction
45.3%
death-coded share
Dog
most-affected species
Bedinvetmab
most-associated drug
Verify with FDA CVM →
53
Total Reports
24
Deaths
45.3%
Death Rate

Species Most Affected

Dog 42
Cat 10
Human 1

Breeds Most Affected

Domestic Shorthair 9
Dog (unknown) 5
Retriever - Golden 4
Crossbred Canine/dog 3
Retriever - Labrador 3
Shepherd Dog - Australian 2
Shepherd Dog - German 2
Terrier - Bull - Staffordshire 2
Collie - Border 2
Terrier - Bull - American Pit 2

Associated Drugs

Bedinvetmab 18
Milbemycin Oxime + Spinosad 7
Gabapentin 7
Carprofen 4
Maropitant Citrate 3
Emodepside + Praziquantel 2
Subcutaneous Fluids 2
Moxidectin 2
Fluralaner Chew Tablets 2
Buprenorphine 2
Diphenhydramine Hcl 2
Afoxolaner 2
Cefovecin 2
Galliprant 2
Vetprofen 2
Grapiprant 2
Frunevetmab 2
Enrofloxacin 1
Tilmicosin Phosphate 1
Melarsomine Dihydrochloride Injection 1

Hyposensitivity to pain Reaction Insights

53 reports name Hyposensitivity to pain; 24 recorded a death outcome (45.3% of reported events, not a population-level mortality rate). VeDDRA code: 1968.

By species: Dog (42 reports), Cat (10 reports), Human (1 reports). By breed: Domestic Shorthair (9), Dog (unknown) (5), Retriever - Golden (4).

Most co-reported drugs: Bedinvetmab (18 reports), Milbemycin Oxime + Spinosad (7 reports), Gabapentin (7 reports), Carprofen (4 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.