Reaction profile

The FDA adverse-event record for renal tubular disorder

80 FDA adverse-event reports reference renal tubular disorder (VeDDRA 2145). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#1506 of 2,481
by report volume (all reactions)
80
reports citing this reaction
75.0%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Renal tubular disorder has 80 reports now versus 78 in that prior snapshot: 2 more (2.6%).

Report change
+2
Death-coded reports
+0
Death-coded share
−1.9 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Renal tubular disorder changes

FDA AER · VeDDRA plate

Code 2145 VOL-LOW

VOL-LOW · DEATH-HOT · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 80 reports
  • DEATH-HOT 75.0%
  • MID-PACK #1506/2481
  • PHOTO-FINISH Cardiac neoplasm
  • SPECIES-DOG Dog · 56
  • DRUG-LEAD Milbemycin Oxime… · 20
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Cardiac neoplasm (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Report-volume neighbourhood around Renal tubular disorder

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Cardiac neoplasm · near80Dilated renal pelvis · near80Erythema multiforme · near80Hernia NOS · near80Renal tubular disorder · thi…80Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Renal tubular disorder

Renal tubular disorder: high death-coded share in the FDA AER plate

Signature read: Renal tubular disorder's 75.0% death-coded share is among the highest in the openFDA reaction corpus. Report volume sits in the middle third of the reaction corpus. Death-coded share is upper-third: 60 of 80 reports (75.0% of named reports). Nearest volume peer: Cardiac neoplasm (±0 reports). Lead species Dog (56). Lead co-reported drug Milbemycin Oxime + Spinosad (20).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 56
Cat 14
Horse 4
Parrot 2
Cattle 1
Monkey 1
Other Rodents 1
Mouse 1

Breeds Most Affected

Domestic Shorthair 6
Crossbred Canine/dog 5
Terrier - Jack Russell 4
Retriever - Labrador 4
Rottweiler 3
Beagle 2
Boxer (German Boxer) 2
Shepherd Dog - German 2
Terrier (unspecified) 2
Dog (unknown) 2

Associated Drugs

Milbemycin Oxime + Spinosad 20
Meloxicam 9
Fluralaner Chew Tablets 6
Buprenorphine 6
Oclacitinib Maleate 5
Carprofen 5
Famotidine 5
Gabapentin 5
Doxycycline 4
Afoxolaner 4
Tramadol 4
Prednisone 4
Ketamine 4
Isoflurane 4
Fluralaner 13.64% 12-Week Chew 4
Maropitant Citrate 4
Spinosad 3
Trilostane 3
Cephalexin 3
Clodronate Disodium 3

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Renal tubular disorder, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (80 here).

Similar death-coded share

Nearest other reactions by death-coded share (75.0% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Renal tubular disorder (#1506 of 2,481 by report volume); death-coded 75.0%. PlainBreed reaction plate · death-coded share stamp 75.0% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →