Reaction profile

The FDA adverse-event record for renal tubular disorder

75 FDA adverse-event reports reference renal tubular disorder (VeDDRA 2145). See the species, breeds, and drugs most associated with it below.

75
reports citing this reaction
76.0%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
75
Total Reports
57
Deaths
76.0%
Death Rate

Species Most Affected

Dog 54
Cat 13
Horse 2
Parrot 2
Cattle 1
Monkey 1
Other Rodents 1
Mouse 1

Breeds Most Affected

Domestic Shorthair 6
Terrier - Jack Russell 4
Retriever - Labrador 4
Rottweiler 3
Crossbred Canine/dog 3
Beagle 2
Boxer (German Boxer) 2
Shepherd Dog - German 2
Terrier (unspecified) 2
Chihuahua 2

Associated Drugs

Milbemycin Oxime + Spinosad 20
Meloxicam 9
Fluralaner Chew Tablets 6
Buprenorphine 6
Oclacitinib Maleate 5
Carprofen 5
Famotidine 5
Gabapentin 5
Afoxolaner 4
Tramadol 4
Ketamine 4
Isoflurane 4
Spinosad 3
Trilostane 3
Doxycycline 3
Cephalexin 3
Ciprofloxacin 3
Sucralfate 3
Prednisone 3
Fluralaner 13.64% 12-Week Chew 3

Renal tubular disorder Reaction Insights

75 reports name Renal tubular disorder; 57 recorded a death outcome (76.0% of reported events, not a population-level mortality rate). VeDDRA code: 2145.

By species: Dog (54 reports), Cat (13 reports), Horse (2 reports). By breed: Domestic Shorthair (6), Terrier - Jack Russell (4), Retriever - Labrador (4).

Most co-reported drugs: Milbemycin Oxime + Spinosad (20 reports), Meloxicam (9 reports), Fluralaner Chew Tablets (6 reports), Buprenorphine (6 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.