Reaction profile

The FDA adverse-event record for hypotension

1,676 FDA reports name hypotension, a high-volume reaction in the CVM extract (VeDDRA 228). Plate stamps and neighbourhood peers follow.

#266 of 2,481
by report volume (all reactions)
1,676
reports citing this reaction
30.1%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Hypotension has 1,676 reports now versus 1,633 in that prior snapshot: 43 more (2.6%).

Report change
+43
Death-coded reports
+10
Death-coded share
−0.2 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Hypotension changes

FDA AER · VeDDRA plate

Code 228 VOL-MID

VOL-MID · DEATH-HOT · UPPER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 1,676 reports
  • DEATH-HOT 30.1%
  • UPPER-Q #266/2481
  • PHOTO-FINISH Mucous stool
  • SPECIES-DOG Dog · 1,219
  • DRUG-LEAD Moxidectin · 334
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Mucous stool (±5 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Hypotension

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Renal disorder NOS · near1684Mucous stool · near1681Hypotension · this reaction1676Sleepiness - systemic… · near1665Nasal discharge · near1662Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Hypotension

Hypotension: high death-coded share in the FDA AER plate

Signature read: 505 death-coded reports is a heavy tail count for Hypotension in the CVM extract. Report volume is upper-third scale: 1,676 named reports in the openFDA extract. Death-coded share is upper-third: 505 of 1,676 reports (30.1% of named reports). Nearest volume peer: Mucous stool (±5 reports). Lead species Dog (1,219). Lead co-reported drug Moxidectin (334).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 1,219
Cat 406
Horse 20
Human 16
Other 4
Rabbit 3
Cattle 2
Other Canids 1
Monkey 1
Lion 1

Breeds Most Affected

Domestic Shorthair 207
Retriever - Labrador 115
Terrier - Bull - American Pit 77
Crossbred Canine/dog 71
Chihuahua 55
Dog (unknown) 48
Terrier - Yorkshire 48
Boxer (German Boxer) 44
Shih Tzu 41
Retriever - Golden 41

Associated Drugs

Moxidectin 334
Maropitant Citrate 251
Isoflurane 186
Propofol 139
Buprenorphine 125
Carprofen 123
Dexmedetomidine Hydrochloride 87
Gabapentin 82
Butorphanol 80
Cefovecin 67
Ketamine 65
Meloxicam 60
Dexamethasone 59
Capromorelin 59
Diphenhydramine Hcl 58
Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str 58
Rabies Virus, Kv 56
Rabies Virus, 55
Alfaxalone 53
Epinephrine 51

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Hypotension, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (1,676 here).

Similar death-coded share

Nearest other reactions by death-coded share (30.1% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Hypotension (#266 of 2,481 by report volume); death-coded 30.1%. PlainBreed reaction plate · death-coded report count stamp 505 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →