Reaction profile

The FDA adverse-event record for hypotension

1,576 FDA adverse-event reports reference hypotension (VeDDRA 228). See the species, breeds, and drugs most associated with it below.

1,576
reports citing this reaction
29.6%
death-coded share
Dog
most-affected species
Moxidectin
most-associated drug
Verify with FDA CVM →
1,576
Total Reports
467
Deaths
29.6%
Death Rate

Species Most Affected

Dog 1,166
Cat 362
Horse 19
Human 16
Other 3
Cattle 2
Rabbit 2
Other Canids 1
Monkey 1
Lion 1

Breeds Most Affected

Domestic Shorthair 176
Retriever - Labrador 111
Terrier - Bull - American Pit 75
Crossbred Canine/dog 69
Chihuahua 51
Terrier - Yorkshire 47
Dog (unknown) 45
Boxer (German Boxer) 44
Shih Tzu 41
Retriever - Golden 40

Associated Drugs

Moxidectin 321
Maropitant Citrate 227
Isoflurane 174
Propofol 130
Carprofen 119
Buprenorphine 110
Dexmedetomidine Hydrochloride 85
Butorphanol 73
Gabapentin 69
Cefovecin 64
Ketamine 61
Meloxicam 58
Dexamethasone 58
Diphenhydramine Hcl 58
Rabies Virus, 55
Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str 54
Alfaxalone 50
Epinephrine 49
Rabies Virus, Kv 47
Midazolam 46

Hypotension Reaction Insights

1,576 reports name Hypotension; 467 recorded a death outcome (29.6% of reported events, not a population-level mortality rate). VeDDRA code: 228.

By species: Dog (1,166 reports), Cat (362 reports), Horse (19 reports). By breed: Domestic Shorthair (176), Retriever - Labrador (111), Terrier - Bull - American Pit (75).

Most co-reported drugs: Moxidectin (321 reports), Maropitant Citrate (227 reports), Isoflurane (174 reports), Propofol (130 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.