Reaction profile

The FDA adverse-event record for liver disorder nos

1,335 FDA reports name liver disorder nos, a high-volume reaction in the CVM extract (VeDDRA 1943). Plate stamps and neighbourhood peers follow.

#311 of 2,481
by report volume (all reactions)
1,335
reports citing this reaction
41.3%
death-coded share
Dog
most-affected species
Verify with FDA CVM →

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Liver disorder NOS has 1,335 reports now versus 1,327 in that prior snapshot: 8 more (0.6%).

Report change
+8
Death-coded reports
+2
Death-coded share
−0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Liver disorder NOS changes

FDA AER · VeDDRA plate

Code 1943 VOL-MID

VOL-MID · DEATH-HOT · UPPER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 1,335 reports
  • DEATH-HOT 41.3%
  • UPPER-Q #311/2481
  • PHOTO-FINISH Alopecia NOS
  • SPECIES-DOG Dog · 1,122
  • DRUG-LEAD Carprofen · 209
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Alopecia NOS (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Liver disorder NOS

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Alopecia NOS · near1335Liver disorder NOS · this re…1335INEFFECTIVE, COCCIDIA · near1334Glazed eye · near1333Underfilling, Bottles · near1333Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Liver disorder NOS

Liver disorder NOS: high death-coded share in the FDA AER plate

Signature read: 551 death-coded reports is a heavy tail count for Liver disorder NOS in the CVM extract. Report volume is upper-third scale: 1,335 named reports in the openFDA extract. Death-coded share is upper-third: 551 of 1,335 reports (41.3% of named reports). Nearest volume peer: Alopecia NOS (±0 reports). Lead species Dog (1,122). Lead co-reported drug Carprofen (209).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 1,122
Cat 151
Cattle 40
Chicken 6
Human 6
Pig 4
Horse 3
Other Birds 1
Ferret 1
Hedgehog 1

Breeds Most Affected

Retriever - Labrador 176
Domestic Shorthair 86
Dog (unknown) 70
Crossbred Canine/dog 66
Chihuahua 40
Shih Tzu 39
Retriever - Golden 36
Terrier - Yorkshire 32
Shepherd Dog - German 27
Boxer (German Boxer) 26

Associated Drugs

Carprofen 209
Milbemycin Oxime + Spinosad 183
Maropitant Citrate 111
Oclacitinib Maleate 89
Trilostane 81
Spinosad 79
Afoxolaner 77
Fluralaner Chew Tablets 58
Ivermectin + Pyrantel As Pamoate Salt 51
Fluralaner 13.64% 12-Week Chew 48
Gabapentin 47
Enrofloxacin 43
Prednisone 37
Metronidazole 33
Sam-E, Silybin, Vitamin E, Zinc 33
Tramadol 30
Famotidine 30
Cefovecin 30
Bedinvetmab 30
Grapiprant 29

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Liver disorder NOS, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (1,335 here).

Alopecia NOS 1,335 INEFFECTIVE, COCCIDIA 1,334 Glazed eye 1,333 Underfilling, Bottles 1,333

Similar death-coded share

Nearest other reactions by death-coded share (41.3% here), distinct from the volume row.

Foam in the mouth 41.3% Renal disorder NOS 41.2% Hyporeflexia 41.4% Weak pulse 41.1%

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Liver disorder NOS (#311 of 2,481 by report volume); death-coded 41.3%. PlainBreed reaction plate · death-coded report count stamp 551 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →