Reaction profile

The FDA adverse-event record for liver disorder nos

1,301 FDA adverse-event reports reference liver disorder nos (VeDDRA 1943). See the species, breeds, and drugs most associated with it below.

1,301
reports citing this reaction
41.3%
death-coded share
Dog
most-affected species
Carprofen
most-associated drug
Verify with FDA CVM →
1,301
Total Reports
537
Deaths
41.3%
Death Rate

Species Most Affected

Dog 1,098
Cat 147
Cattle 36
Chicken 6
Human 5
Horse 3
Pig 3
Other Birds 1
Ferret 1
Hedgehog 1

Breeds Most Affected

Retriever - Labrador 174
Domestic Shorthair 85
Dog (unknown) 68
Crossbred Canine/dog 65
Shih Tzu 38
Chihuahua 38
Retriever - Golden 34
Terrier - Yorkshire 32
Shepherd Dog - German 27
Boxer (German Boxer) 26

Associated Drugs

Carprofen 207
Milbemycin Oxime + Spinosad 183
Maropitant Citrate 106
Oclacitinib Maleate 88
Spinosad 79
Afoxolaner 75
Trilostane 72
Fluralaner Chew Tablets 58
Ivermectin + Pyrantel As Pamoate Salt 51
Fluralaner 13.64% 12-Week Chew 46
Gabapentin 42
Enrofloxacin 41
Prednisone 36
Sam-E, Silybin, Vitamin E, Zinc 33
Metronidazole 31
Tramadol 30
Cefovecin 30
Famotidine 29
Grapiprant 29
Deracoxib 28

Liver disorder NOS Reaction Insights

1,301 reports name Liver disorder NOS; 537 recorded a death outcome (41.3% of reported events, not a population-level mortality rate). VeDDRA code: 1943.

By species: Dog (1,098 reports), Cat (147 reports), Cattle (36 reports). By breed: Retriever - Labrador (174), Domestic Shorthair (85), Dog (unknown) (68).

Most co-reported drugs: Carprofen (207 reports), Milbemycin Oxime + Spinosad (183 reports), Maropitant Citrate (106 reports), Oclacitinib Maleate (88 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.