Reaction profile

The FDA adverse-event record for reduced reflexes

155 FDA adverse-event reports reference reduced reflexes (VeDDRA 676). See the species, breeds, and drugs most associated with it below.

155
reports citing this reaction
27.1%
death-coded share
Dog
most-affected species
Bedinvetmab
most-associated drug
Verify with FDA CVM →
155
Total Reports
42
Deaths
27.1%
Death Rate

Species Most Affected

Dog 132
Cat 21
Horse 1
Rat 1

Breeds Most Affected

Retriever - Labrador 28
Domestic Shorthair 15
Retriever - Golden 10
Chihuahua 9
Crossbred Canine/dog 5
Pit Bull 4
Shepherd Dog - German 4
Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog) 4
Mountain Dog - Bernese 3
Spaniel - King Charles Cavalier 3

Associated Drugs

Bedinvetmab 34
Gabapentin 23
Carprofen 16
Milbemycin Oxime + Spinosad 13
Moxidectin 11
Maropitant Citrate 11
Cefovecin 8
Buprenorphine 7
Amantadine 7
Rabies Virus, Kv 6
Oclacitinib Maleate 6
Galliprant 6
Frunevetmab 6
Spinosad 5
Tramadol 5
Dexamethasone Sodium Phosphate 5
Prednisolone 5
Fluralaner Chew Tablets 5
Grapiprant 5
Cephalexin 4

Reduced reflexes Reaction Insights

155 reports name Reduced reflexes; 42 recorded a death outcome (27.1% of reported events, not a population-level mortality rate). VeDDRA code: 676.

By species: Dog (132 reports), Cat (21 reports), Horse (1 reports). By breed: Retriever - Labrador (28), Domestic Shorthair (15), Retriever - Golden (10).

Most co-reported drugs: Bedinvetmab (34 reports), Gabapentin (23 reports), Carprofen (16 reports), Milbemycin Oxime + Spinosad (13 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.