Reaction profile

The FDA adverse-event record for reduced reflexes

172 FDA adverse-event reports reference reduced reflexes (VeDDRA 676). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#1115 of 2,481
by report volume (all reactions)
172
reports citing this reaction
28.5%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Reduced reflexes has 172 reports now versus 166 in that prior snapshot: 6 more (3.6%).

Report change
+6
Death-coded reports
+4
Death-coded share
+1.4 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Reduced reflexes changes

FDA AER · VeDDRA plate

Code 676 VOL-LOW

VOL-LOW · DEATH-HOT · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 172 reports
  • DEATH-HOT 28.5%
  • MID-PACK #1115/2481
  • PHOTO-FINISH Strabismus
  • SPECIES-DOG Dog · 146
  • DRUG-LEAD Bedinvetmab · 43
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Strabismus (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Report-volume neighbourhood around Reduced reflexes

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Angioedema · near173Reduced reflexes · this reac…172Strabismus · near172Stridor (Upper respir… · near172Abrasion · near171Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Reduced reflexes

Reduced reflexes: high death-coded share in the FDA AER plate

Signature read: Reduced reflexes's 28.5% death-coded share is among the highest in the openFDA reaction corpus. Report volume sits in the middle third of the reaction corpus. Death-coded share is upper-third: 49 of 172 reports (28.5% of named reports). Nearest volume peer: Strabismus (±0 reports). Lead species Dog (146). Lead co-reported drug Bedinvetmab (43).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 146
Cat 24
Horse 1
Rat 1

Breeds Most Affected

Retriever - Labrador 30
Domestic Shorthair 16
Retriever - Golden 10
Chihuahua 9
Shepherd Dog - German 6
Crossbred Canine/dog 5
Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog) 5
Pit Bull 4
Domestic Mediumhair 4
Terrier - Bull - American Pit 4

Associated Drugs

Bedinvetmab 43
Gabapentin 27
Carprofen 16
Milbemycin Oxime + Spinosad 13
Maropitant Citrate 12
Moxidectin 11
Grapiprant 10
Amantadine 9
Cefovecin 8
Buprenorphine 7
Prednisone 7
Oclacitinib Maleate 7
Rabies Virus, Kv 6
Dexamethasone Sodium Phosphate 6
Pyrantel Pamoate;Sarolaner 6
Galliprant 6
Frunevetmab 6
Spinosad 5
Prednisolone 5
Fluralaner Chew Tablets 5

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Reduced reflexes, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar death-coded share

Nearest other reactions by death-coded share (28.5% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Reduced reflexes (#1115 of 2,481 by report volume); death-coded 28.5%. PlainBreed reaction plate · death-coded share stamp 28.5% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →