Reaction profile

The FDA adverse-event record for unable to stand

3,706 FDA reports name unable to stand, a high-volume reaction in the CVM extract (VeDDRA 653). Plate stamps and neighbourhood peers follow.

#127 of 2,481
by report volume (all reactions)
3,706
reports citing this reaction
28.4%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Unable to stand has 3,706 reports now versus 3,639 in that prior snapshot: 67 more (1.8%).

Report change
+67
Death-coded reports
+24
Death-coded share
+0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Unable to stand changes

FDA AER · VeDDRA plate

Code 653 VOL-MID

VOL-MID · DEATH-HOT · TOP-DECILE · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 3,706 reports
  • DEATH-HOT 28.4%
  • TOP-DECILE #127/2481
  • PHOTO-FINISH INEFFECTIVE, LOSS OF…
  • SPECIES-DOG Dog · 3,248
  • DRUG-LEAD Bedinvetmab · 564
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: INEFFECTIVE, LOSS OF EFFECT (±3 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Unable to stand

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Odor, Abnormal · near3829INEFFECTIVE, LOSS OF… · near3709Unable to stand · this react…3706Limb weakness · near3668Foaming at the mouth · near3606Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Unable to stand

Unable to stand: high death-coded share in the FDA AER plate

Signature read: 1,052 death-coded reports is a heavy tail count for Unable to stand in the CVM extract. Report volume is upper-third scale: 3,706 named reports in the openFDA extract. Death-coded share is upper-third: 1,052 of 3,706 reports (28.4% of named reports). Nearest volume peer: INEFFECTIVE, LOSS OF EFFECT (±3 reports). Lead species Dog (3,248). Lead co-reported drug Bedinvetmab (564).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 3,248
Cat 373
Cattle 43
Horse 24
Sheep 6
Goat 2
Human 2
Rabbit 1
Turkey 1
Other 1

Breeds Most Affected

Retriever - Labrador 373
Crossbred Canine/dog 248
Domestic Shorthair 229
Retriever - Golden 188
Chihuahua 151
Shepherd Dog - German 120
Terrier - Yorkshire 116
Dog (unknown) 104
Boxer (German Boxer) 98
Shepherd Dog - Australian 97

Associated Drugs

Bedinvetmab 564
Milbemycin Oxime + Spinosad 451
Carprofen 303
Afoxolaner 264
Gabapentin 214
Maropitant Citrate 191
Fluralaner 13.64% 12-Week Chew 146
Pyrantel Pamoate;Sarolaner 137
Moxidectin 136
Ivermectin + Pyrantel As Pamoate Salt 133
Spinosad 127
Fluralaner Chew Tablets 118
Cefovecin 114
Sarolaner 100
Prednisone 92
Grapiprant 86
Oclacitinib Maleate 85
Trilostane 82
Buprenorphine 77
Milbemycin Oxime + Praziquantel 77

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Unable to stand, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (3,706 here).

Similar death-coded share

Nearest other reactions by death-coded share (28.4% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Unable to stand (#127 of 2,481 by report volume); death-coded 28.4%. PlainBreed reaction plate · death-coded report count stamp 1,052 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →