Reaction profile

The FDA adverse-event record for unable to stand

3,524 FDA adverse-event reports reference unable to stand (VeDDRA 653). See the species, breeds, and drugs most associated with it below.

3,524
reports citing this reaction
28.0%
death-coded share
Dog
most-affected species
Bedinvetmab
most-associated drug
Verify with FDA CVM →
3,524
Total Reports
987
Deaths
28.0%
Death Rate

Species Most Affected

Dog 3,112
Cat 334
Cattle 36
Horse 24
Sheep 6
Goat 2
Human 2
Rabbit 1
Turkey 1
Other 1

Breeds Most Affected

Retriever - Labrador 344
Crossbred Canine/dog 239
Domestic Shorthair 201
Retriever - Golden 178
Chihuahua 146
Terrier - Yorkshire 114
Shepherd Dog - German 109
Dog (unknown) 101
Boxer (German Boxer) 94
Shepherd Dog - Australian 89

Associated Drugs

Bedinvetmab 497
Milbemycin Oxime + Spinosad 451
Carprofen 280
Afoxolaner 258
Gabapentin 185
Maropitant Citrate 181
Fluralaner 13.64% 12-Week Chew 137
Moxidectin 135
Ivermectin + Pyrantel As Pamoate Salt 133
Spinosad 127
Pyrantel Pamoate;Sarolaner 127
Fluralaner Chew Tablets 118
Cefovecin 111
Sarolaner 99
Prednisone 88
Grapiprant 82
Oclacitinib Maleate 81
Trilostane 80
Milbemycin Oxime + Praziquantel 77
Buprenorphine 69

Unable to stand Reaction Insights

3,524 reports name Unable to stand; 987 recorded a death outcome (28.0% of reported events, not a population-level mortality rate). VeDDRA code: 653.

By species: Dog (3,112 reports), Cat (334 reports), Cattle (36 reports). By breed: Retriever - Labrador (344), Crossbred Canine/dog (239), Domestic Shorthair (201).

Most co-reported drugs: Bedinvetmab (497 reports), Milbemycin Oxime + Spinosad (451 reports), Carprofen (280 reports), Afoxolaner (258 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.