Reaction profile

The FDA adverse-event record for pulmonary oedema

961 FDA adverse-event reports reference pulmonary oedema (VeDDRA 848). See the species, breeds, and drugs most associated with it below.

961
reports citing this reaction
68.5%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
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961
Total Reports
658
Deaths
68.5%
Death Rate

Species Most Affected

Dog 590
Cat 267
Cattle 78
Horse 8
Sheep 4
Goat 4
Pig 3
Human 2
Other Birds 1
Llama 1

Breeds Most Affected

Domestic Shorthair 184
Chihuahua 36
Crossbred Canine/dog 31
Shih Tzu 29
Dachshund (unspecified) 24
Retriever - Labrador 23
Terrier - Yorkshire 22
Shepherd Dog - German 21
Maltese 21
Spitz - German Pomeranian 20

Associated Drugs

Milbemycin Oxime + Spinosad 113
Furosemide 79
Cefovecin 75
Maropitant Citrate 73
Butorphanol 51
Moxidectin 50
Dexmedetomidine Hydrochloride 49
Isoflurane 48
Spinosad 46
Buprenorphine 44
Dexamethasone 41
Monensin Sodium 40
Meloxicam 38
Carprofen 35
Afoxolaner 31
Famotidine 30
Melarsomine Dihydrochloride Injection 30
Melarsomine Dihydrochloride 30
Selamectin 29
Pimobendan 29

Pulmonary oedema Reaction Insights

961 reports name Pulmonary oedema; 658 recorded a death outcome (68.5% of reported events, not a population-level mortality rate). VeDDRA code: 848.

By species: Dog (590 reports), Cat (267 reports), Cattle (78 reports). By breed: Domestic Shorthair (184), Chihuahua (36), Crossbred Canine/dog (31).

Most co-reported drugs: Milbemycin Oxime + Spinosad (113 reports), Furosemide (79 reports), Cefovecin (75 reports), Maropitant Citrate (73 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.