Reaction profile

The FDA adverse-event record for itchy skin

970 FDA adverse-event reports reference itchy skin (VeDDRA 1145). See the species, breeds, and drugs most associated with it below.

970
reports citing this reaction
0.8%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
970
Total Reports
8
Deaths
0.8%
Death Rate

Species Most Affected

Dog 796
Cat 116
Human 42
Horse 9
Cattle 6
Donkey 1

Breeds Most Affected

Domestic Shorthair 82
Retriever - Labrador 73
Crossbred Canine/dog 59
Unknown 43
Dog (unknown) 41
Retriever - Golden 38
Chihuahua 36
Terrier - Yorkshire 35
Shih Tzu 32
Shepherd Dog - German 28

Associated Drugs

Milbemycin Oxime + Spinosad 157
Afoxolaner 117
Fluralaner Chew Tablets 66
Pyrantel Pamoate;Sarolaner 58
Moxidectin 49
Oclacitinib Maleate 40
Milbemycin Oxime + Praziquantel 39
Fluralaner Spot-On Solution 37
Frunevetmab 35
Spinosad 32
Selamectin 31
Ivermectin + Pyrantel As Pamoate Salt 29
Fluralaner 13.64% 12-Week Chew 29
Prednisone 26
Anti-Il31 Mab Mcs Lot #1283563 23
Trilostane 22
Sarolaner 20
Selamectin;Sarolaner 20
Levothyroxine Sodium 18
Lotilaner 17

Itchy skin Reaction Insights

970 reports name Itchy skin; 8 recorded a death outcome (0.8% of reported events, not a population-level mortality rate). VeDDRA code: 1145.

By species: Dog (796 reports), Cat (116 reports), Human (42 reports). By breed: Domestic Shorthair (82), Retriever - Labrador (73), Crossbred Canine/dog (59).

Most co-reported drugs: Milbemycin Oxime + Spinosad (157 reports), Afoxolaner (117 reports), Fluralaner Chew Tablets (66 reports), Pyrantel Pamoate;Sarolaner (58 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.