Reaction profile

The FDA adverse-event record for itchy skin

1,005 FDA reports name itchy skin, a high-volume reaction in the CVM extract (VeDDRA 1145). Plate stamps and neighbourhood peers follow.

#392 of 2,481
by report volume (all reactions)
1,005
reports citing this reaction
0.8%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Itchy skin has 1,005 reports now versus 994 in that prior snapshot: 11 more (1.1%).

Report change
+11
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Itchy skin changes

FDA AER · VeDDRA plate

Code 1145 VOL-MID

VOL-MID · DEATH-RARE · UPPER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 1,005 reports
  • DEATH-RARE 0.8%
  • UPPER-Q #392/2481
  • PHOTO-FINISH Decreased haemoglobin
  • SPECIES-DOG Dog · 821
  • DRUG-LEAD Milbemycin Oxime… · 157
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Decreased haemoglobin (±2 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Itchy skin

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Paddling · near1009Pulmonary oedema · near1009Decreased haemoglobin · near1007Itchy skin · this reaction1005Lack of efficacy (hea… · near1001Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Itchy skin

Itchy skin: low death-coded share in the FDA AER plate

Signature read: Itchy skin's 0.8% death-coded share is among the lowest in the openFDA reaction corpus. Report volume is upper-third scale: 1,005 named reports in the openFDA extract. Death-coded share is lower-third: 8 of 1,005 reports (0.8% of named reports). Nearest volume peer: Decreased haemoglobin (±2 reports). Lead species Dog (821). Lead co-reported drug Milbemycin Oxime + Spinosad (157).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Milbemycin Oxime + Spinosad appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 821
Cat 124
Human 43
Horse 10
Cattle 6
Donkey 1

Breeds Most Affected

Domestic Shorthair 86
Retriever - Labrador 73
Crossbred Canine/dog 60
Unknown 45
Dog (unknown) 42
Retriever - Golden 40
Chihuahua 36
Terrier - Yorkshire 35
Shih Tzu 33
Shepherd Dog - German 30

Associated Drugs

Milbemycin Oxime + Spinosad 157
Afoxolaner 119
Fluralaner Chew Tablets 66
Pyrantel Pamoate;Sarolaner 60
Moxidectin 52
Frunevetmab 41
Oclacitinib Maleate 40
Milbemycin Oxime + Praziquantel 39
Fluralaner Spot-On Solution 38
Spinosad 32
Selamectin 31
Fluralaner 13.64% 12-Week Chew 30
Ivermectin + Pyrantel As Pamoate Salt 29
Prednisone 29
Trilostane 25
Anti-Il31 Mab Mcs Lot #1283563 24
Sarolaner 21
Selamectin;Sarolaner 21
Gabapentin 20
Levothyroxine Sodium 18

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Itchy skin, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (1,005 here).

Similar death-coded share

Nearest other reactions by death-coded share (0.8% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Itchy skin (#392 of 2,481 by report volume); death-coded 0.8%. PlainBreed reaction plate · death-coded share stamp 0.8% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →