Reaction profile

The FDA adverse-event record for paddling

981 FDA adverse-event reports reference paddling (VeDDRA 1226). See the species, breeds, and drugs most associated with it below.

981
reports citing this reaction
16.3%
death-coded share
Dog
most-affected species
Afoxolaner
most-associated drug
Verify with FDA CVM →
981
Total Reports
160
Deaths
16.3%
Death Rate

Species Most Affected

Dog 844
Cat 83
Horse 18
Pig 14
Cattle 14
Turkey 5
Chicken 1
Sheep 1
Goat 1

Breeds Most Affected

Crossbred Canine/dog 94
Retriever - Labrador 75
Retriever - Golden 49
Domestic Shorthair 37
Chihuahua 36
Shepherd Dog - German 31
Shepherd Dog - Australian 29
Shih Tzu 28
Boxer (German Boxer) 28
Dog (unknown) 25

Associated Drugs

Afoxolaner 173
Fluralaner Chew Tablets 125
Fluralaner 13.64% 12-Week Chew 78
Ivermectin + Pyrantel As Pamoate Salt 77
Propofol 56
Alfaxalone 41
Milbemycin Oxime + Spinosad 35
Isoflurane 35
Buprenorphine 32
Butorphanol 32
Maropitant Citrate 30
Pyrantel Pamoate;Sarolaner 23
Bedinvetmab 23
Carprofen 22
Midazolam 20
Oclacitinib Maleate 17
Sarolaner 16
Ketamine Hydrochloride 15
Fluralaner Spot-On Solution 15
Ketamine 14

Paddling Reaction Insights

981 reports name Paddling; 160 recorded a death outcome (16.3% of reported events, not a population-level mortality rate). VeDDRA code: 1226.

By species: Dog (844 reports), Cat (83 reports), Horse (18 reports). By breed: Crossbred Canine/dog (94), Retriever - Labrador (75), Retriever - Golden (49).

Most co-reported drugs: Afoxolaner (173 reports), Fluralaner Chew Tablets (125 reports), Fluralaner 13.64% 12-Week Chew (78 reports), Ivermectin + Pyrantel As Pamoate Salt (77 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.