Reaction profile

The FDA adverse-event record for paddling

1,009 FDA reports name paddling, a high-volume reaction in the CVM extract (VeDDRA 1226). Plate stamps and neighbourhood peers follow.

#389 of 2,481
by report volume (all reactions)
1,009
reports citing this reaction
16.1%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Paddling has 1,009 reports now versus 1,004 in that prior snapshot: 5 more (0.5%).

Report change
+5
Death-coded reports
+0
Death-coded share
−0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Paddling changes

FDA AER · VeDDRA plate

Code 1226 VOL-MID

VOL-MID · DEATH-ELEV · UPPER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 1,009 reports
  • DEATH-ELEV 16.1%
  • UPPER-Q #389/2481
  • PHOTO-FINISH Pulmonary oedema
  • SPECIES-DOG Dog · 870
  • DRUG-LEAD Afoxolaner · 178
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Pulmonary oedema (±0 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Paddling

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Paddling · this reaction1009Pulmonary oedema · near1009Decreased haemoglobin · near1007Itchy skin · near1005Lack of efficacy (hea… · near1001Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Paddling

What the FDA AER plate says about Paddling

Signature read: 162 death-coded reports is a heavy tail count for Paddling in the CVM extract. Report volume is upper-third scale: 1,009 named reports in the openFDA extract. 162 of 1,009 reports were death-coded (16.1% of named reports, not a population mortality rate). Nearest volume peer: Pulmonary oedema (±0 reports). Lead species Dog (870). Lead co-reported drug Afoxolaner (178).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Afoxolaner appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 870
Cat 84
Horse 18
Cattle 15
Pig 14
Turkey 5
Chicken 1
Sheep 1
Goat 1

Breeds Most Affected

Crossbred Canine/dog 96
Retriever - Labrador 77
Retriever - Golden 50
Chihuahua 38
Domestic Shorthair 37
Shepherd Dog - Australian 31
Shepherd Dog - German 31
Shih Tzu 29
Boxer (German Boxer) 29
Dog (unknown) 25

Associated Drugs

Afoxolaner 178
Fluralaner Chew Tablets 125
Fluralaner 13.64% 12-Week Chew 79
Ivermectin + Pyrantel As Pamoate Salt 78
Propofol 57
Alfaxalone 42
Milbemycin Oxime + Spinosad 35
Isoflurane 35
Buprenorphine 32
Butorphanol 32
Maropitant Citrate 31
Pyrantel Pamoate;Sarolaner 26
Bedinvetmab 23
Carprofen 22
Midazolam 21
Oclacitinib Maleate 17
Sarolaner 16
Ketamine Hydrochloride 15
Fluralaner Spot-On Solution 15
Ketamine 14

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Paddling, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (1,009 here).

Similar death-coded share

Nearest other reactions by death-coded share (16.1% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Paddling (#389 of 2,481 by report volume); death-coded 16.1%. PlainBreed reaction plate · death-coded report count stamp 162 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →