Reaction profile

The FDA adverse-event record for pulmonary congestion

550 FDA adverse-event reports reference pulmonary congestion (VeDDRA 843). See the species, breeds, and drugs most associated with it below.

550
reports citing this reaction
68.5%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
550
Total Reports
377
Deaths
68.5%
Death Rate

Species Most Affected

Dog 352
Cat 109
Cattle 69
Horse 5
Pig 5
Human 3
Guinea Pig 2
Sheep 2
Rabbit 1
Chicken 1

Breeds Most Affected

Domestic Shorthair 58
Crossbred Canine/dog 36
Retriever - Labrador 31
Shepherd Dog - German 24
Cattle (other) 17
Domestic (unspecified) 16
Dachshund (unspecified) 13
Terrier - Yorkshire 13
Chihuahua 13
Spitz - German Pomeranian 12

Associated Drugs

Milbemycin Oxime + Spinosad 87
Spinosad 48
Buprenorphine 29
Melarsomine Dihydrochloride 24
Cefovecin 24
Maropitant Citrate 24
Carprofen 20
Enrofloxacin 18
Prednisone 18
Afoxolaner 18
Fluralaner Chew Tablets 18
Isoflurane 17
Robenacoxib 17
Moxidectin 16
Rabies Vaccine 16
Ivermectin + Pyrantel As Pamoate Salt 16
Dexamethasone 15
Pimobendan 14
Monensin Sodium 14
Tulathromycin 14

Pulmonary congestion Reaction Insights

550 reports name Pulmonary congestion; 377 recorded a death outcome (68.5% of reported events, not a population-level mortality rate). VeDDRA code: 843.

By species: Dog (352 reports), Cat (109 reports), Cattle (69 reports). By breed: Domestic Shorthair (58), Crossbred Canine/dog (36), Retriever - Labrador (31).

Most co-reported drugs: Milbemycin Oxime + Spinosad (87 reports), Spinosad (48 reports), Buprenorphine (29 reports), Melarsomine Dihydrochloride (24 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.