Reaction profile

The FDA adverse-event record for pulmonary fibrosis

46 FDA adverse-event reports reference pulmonary fibrosis (VeDDRA 2259). See the species, breeds, and drugs most associated with it below.

46
reports citing this reaction
78.3%
death-coded share
Dog
most-affected species
Rabacfosadine
most-associated drug
Verify with FDA CVM →
46
Total Reports
36
Deaths
78.3%
Death Rate

Species Most Affected

Dog 39
Cat 4
Cattle 3

Breeds Most Affected

Retriever - Golden 5
Crossbred Canine/dog 4
Retriever - Labrador 4
Domestic Shorthair 4
Cattle (unknown) 3
Coton de Tuléar 3
Shih Tzu 2
Spaniel - Cocker American 2
Terrier - Yorkshire 2
Pit Bull 2

Associated Drugs

Rabacfosadine 14
Rabacfosadine Succinate 8
Maropitant 7
Enrofloxacin 7
Prednisone 5
Oclacitinib Maleate 4
Fluralaner 4
Grapiprant 4
Gabapentin 4
Buprenorphine 4
Trenbolone; Estradiol; Tylosin Tartrate 3
Escherichia Coli K99 Antibody 3
Flunixin Meglumine 3
Isoflurane 3
Rattlesnake Vaccine 3
Metoclopramide 3
Fluid Therapy 3
Bupivacaine 3
Milbemycin Oxime + Spinosad 2
Cefovecin Sodium 2

Pulmonary fibrosis Reaction Insights

46 reports name Pulmonary fibrosis; 36 recorded a death outcome (78.3% of reported events, not a population-level mortality rate). VeDDRA code: 2259.

By species: Dog (39 reports), Cat (4 reports), Cattle (3 reports). By breed: Retriever - Golden (5), Crossbred Canine/dog (4), Retriever - Labrador (4).

Most co-reported drugs: Rabacfosadine (14 reports), Rabacfosadine Succinate (8 reports), Maropitant (7 reports), Enrofloxacin (7 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.