Reaction profile

The FDA adverse-event record for application site scar

46 FDA adverse-event reports reference application site scar (VeDDRA 2518). See the species, breeds, and drugs most associated with it below.

46
reports citing this reaction
2.2%
death-coded share
Dog
most-affected species
Tigilanol Tiglate
most-associated drug
Verify with FDA CVM →
46
Total Reports
1
Deaths
2.2%
Death Rate

Species Most Affected

Dog 23
Cat 20
Cattle 2
Human 1

Breeds Most Affected

Domestic Shorthair 13
Terrier - Boston 3
Bengal 2
Boxer (German Boxer) 2
Beagle 2
Pit Bull 2
Domestic Mediumhair 2
Retriever - Labrador 2
Terrier - Bull - American Pit 2
Chihuahua 2

Associated Drugs

Tigilanol Tiglate 13
Gabapentin 10
Diphenhydramine 9
Famotidine 8
Prednisone 7
Imidacloprid + Moxidectin 5
Selamectin;Sarolaner 5
Emodepside + Praziquantel 4
Trazodone 4
Butorphanol 4
Fluralaner Spot-On Solution 3
Maropitant Citrate 3
Carprofen 3
Butorphanol Tartrate 3
Dexmedetomidine Hydrochloride 3
Atipamezole 3
Oclacitinib Maleate 3
Unspecified Shampoo 2
Selamectin 2
Prednisolone 2

Application site scar Reaction Insights

46 reports name Application site scar; 1 recorded a death outcome (2.2% of reported events, not a population-level mortality rate). VeDDRA code: 2518.

By species: Dog (23 reports), Cat (20 reports), Cattle (2 reports). By breed: Domestic Shorthair (13), Terrier - Boston (3), Bengal (2).

Most co-reported drugs: Tigilanol Tiglate (13 reports), Gabapentin (10 reports), Diphenhydramine (9 reports), Famotidine (8 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.