Reaction profile

The FDA adverse-event record for profuse bleeding

61 FDA adverse-event reports reference profuse bleeding (VeDDRA 178). See the species, breeds, and drugs most associated with it below.

61
reports citing this reaction
39.3%
death-coded share
Dog
most-affected species
Carprofen
most-associated drug
Verify with FDA CVM →
61
Total Reports
24
Deaths
39.3%
Death Rate

Species Most Affected

Dog 52
Cat 8
Horse 1

Breeds Most Affected

Retriever - Labrador 5
Shepherd Dog - German 4
Shepherd Dog - Australian 3
Crossbred Canine/dog 3
Dachshund (unspecified) 3
Retriever - Golden 3
Dog (unknown) 3
Shih Tzu 3
Domestic Shorthair 2
Domestic Longhair 2

Associated Drugs

Carprofen 12
Isoflurane 7
Buprenorphine 6
Famotidine 5
Ketamine 5
Propofol 5
Enrofloxacin 4
Gabapentin 4
Midazolam Hydrochloride 4
Fluralaner Chew Tablets 4
Maropitant Citrate 4
Cefovecin 3
Metoclopramide 3
Polysulfated Glycosaminoglycan 3
Butorphanol 3
Sevoflurane 3
Dexmedetomidine Hydrochloride 3
Tramadol 3
Firocoxib 3
Meloxicam 3

Profuse bleeding Reaction Insights

61 reports name Profuse bleeding; 24 recorded a death outcome (39.3% of reported events, not a population-level mortality rate). VeDDRA code: 178.

By species: Dog (52 reports), Cat (8 reports), Horse (1 reports). By breed: Retriever - Labrador (5), Shepherd Dog - German (4), Shepherd Dog - Australian (3).

Most co-reported drugs: Carprofen (12 reports), Isoflurane (7 reports), Buprenorphine (6 reports), Famotidine (5 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.