Reaction profile

The FDA adverse-event record for acne

61 FDA adverse-event reports reference acne (VeDDRA 905). See the species, breeds, and drugs most associated with it below.

61
reports citing this reaction
1.6%
death-coded share
Cat
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
61
Total Reports
1
Deaths
1.6%
Death Rate

Species Most Affected

Cat 34
Dog 24
Human 3

Breeds Most Affected

Domestic Shorthair 22
Retriever - Labrador 3
Domestic Longhair 3
Unknown 3
Maine Coon 3
Bulldog 2
Cat (unknown) 2
Boxer (German Boxer) 2
Deutsche Dogge, Great Dane 2
Terrier - Boston 2

Associated Drugs

Milbemycin Oxime + Spinosad 13
Frunevetmab 8
Cefovecin 7
Bexagliflozin 5
Imidacloprid + Moxidectin 4
Afoxolaner 3
Milbemycin Oxime + Praziquantel 3
Oclacitinib Maleate 3
Anti-Il31 Mab Mcs Lot #1283563 3
Selmectin 2
Enrofloxacin 2
Nitenpyram 2
Fipronil 2
Milbemycin Oxime 2
Antibiotic (Unknown) 2
Fluralaner Spot-On Solution 2
Polysulfated Glycosaminoglycan 2
Thiamazole 2
Pyrantel Pamoate;Sarolaner 2
Mirtazapine 2

Acne Reaction Insights

61 reports name Acne; 1 recorded a death outcome (1.6% of reported events, not a population-level mortality rate). VeDDRA code: 905.

By species: Cat (34 reports), Dog (24 reports), Human (3 reports). By breed: Domestic Shorthair (22), Retriever - Labrador (3), Domestic Longhair (3).

Most co-reported drugs: Milbemycin Oxime + Spinosad (13 reports), Frunevetmab (8 reports), Cefovecin (7 reports), Bexagliflozin (5 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.