Reaction profile

The FDA adverse-event record for immune-mediated polyarthritis

48 FDA adverse-event reports reference immune-mediated polyarthritis (VeDDRA 2681). See the species, breeds, and drugs most associated with it below.

48
reports citing this reaction
12.5%
death-coded share
Dog
most-affected species
Carprofen
most-associated drug
Verify with FDA CVM →
48
Total Reports
6
Deaths
12.5%
Death Rate

Species Most Affected

Dog 44
Cat 4

Breeds Most Affected

Retriever - Labrador 9
Crossbred Canine/dog 5
Retriever - Golden 4
Chihuahua 3
Terrier - Bull - American Pit 2
Domestic Shorthair 2
Shepherd Dog - Australian 2
Shepherd Dog - German 2
Dog (unknown) 2
Mountain Dog - Bernese 2

Associated Drugs

Carprofen 11
Bedinvetmab 9
Gabapentin 8
Pyrantel Pamoate;Sarolaner 7
Oclacitinib Maleate 6
Maropitant Citrate 5
Doxycycline 5
Anti-Il31 Mab Mcs Lot #1283563 4
Moxidectin 4
Metronidazole 4
Enrofloxacin 4
Rabies Virus, 3
Prednisone 3
Trazodone 3
Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str 2
Afoxolaner 2
Canine Parvovirus Strain Nl-35-D, P.35-D, 8-2-80;Canine Parainfluenza Virus, Str 2
Fluralaner 13.64% 12-Week Chew 2
Ivermectin / Pyrantel Tablets 2
Ivermectin + Pyrantel 2

Immune-mediated polyarthritis Reaction Insights

48 reports name Immune-mediated polyarthritis; 6 recorded a death outcome (12.5% of reported events, not a population-level mortality rate). VeDDRA code: 2681.

By species: Dog (44 reports), Cat (4 reports). By breed: Retriever - Labrador (9), Crossbred Canine/dog (5), Retriever - Golden (4).

Most co-reported drugs: Carprofen (11 reports), Bedinvetmab (9 reports), Gabapentin (8 reports), Pyrantel Pamoate;Sarolaner (7 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.