Reaction profile

The FDA adverse-event record for lacrimation

62 FDA adverse-event reports reference lacrimation (VeDDRA 439). See the species, breeds, and drugs most associated with it below.

62
reports citing this reaction
0.0%
death-coded share
Dog
most-affected species
Imidacloprid + Moxidectin
most-associated drug
Verify with FDA CVM →
62
Total Reports
0
Deaths
0.0%
Death Rate

Species Most Affected

Dog 26
Cat 24
Human 10
Cattle 2

Breeds Most Affected

Domestic Shorthair 14
Unknown 11
Retriever - Labrador 5
Spitz - German Pomeranian 3
Domestic Longhair 3
Cat (unknown) 2
Chihuahua 2
Deutsche Dogge, Great Dane 2
Dog (other) 1
Pinscher - Miniature 1

Associated Drugs

Imidacloprid + Moxidectin 9
Emodepside + Praziquantel 5
Phenylpropanolamine Hcl 4
Buprenorphine 4
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 3
Milbemycin Oxime + Spinosad 3
Milbemycin Oxime + Praziquantel 3
Lotilaner 3
Imidacloprid And Moxidectin 2
Afoxolaner 2
Fluralaner Chew Tablets 2
Hyaluronic Acid 2
Cefovecin 2
Amoxicillin, Clavulanate Potassium 2
Robenacoxib 2
Maropitant Citrate 2
Dexmedetomidine 2
Ketamine 2
Isoflurane 2
Glycosaminoglycan Polysulfate 1

Lacrimation Reaction Insights

62 reports name Lacrimation; 0 recorded a death outcome (0.0% of reported events, not a population-level mortality rate). VeDDRA code: 439.

By species: Dog (26 reports), Cat (24 reports), Human (10 reports). By breed: Domestic Shorthair (14), Unknown (11), Retriever - Labrador (5).

Most co-reported drugs: Imidacloprid + Moxidectin (9 reports), Emodepside + Praziquantel (5 reports), Phenylpropanolamine Hcl (4 reports), Buprenorphine (4 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.