Reaction profile

The FDA adverse-event record for lacrimation

64 FDA adverse-event reports reference lacrimation (VeDDRA 439). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#1620 of 2,481
by report volume (all reactions)
64
reports citing this reaction
0.0%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Lacrimation has 64 reports now versus 64 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Lacrimation changes

FDA AER · VeDDRA plate

Code 439 VOL-LOW

VOL-LOW · DEATH-RARE · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 64 reports
  • DEATH-RARE 0.0%
  • MID-PACK #1620/2481
  • PHOTO-FINISH Preputial discharge
  • SPECIES-DOG Dog · 27
  • DRUG-LEAD Imidacloprid + Mo… · 9
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Preputial discharge (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Report-volume neighbourhood around Lacrimation

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Acne · near65Lacrimation · this reaction64Preputial discharge · near64Snoring · near64Spherocytosis · near64Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Lacrimation

Lacrimation: low death-coded share in the FDA AER plate

Signature read: Lacrimation's 0.0% death-coded share is among the lowest in the openFDA reaction corpus. Report volume sits in the middle third of the reaction corpus. Death-coded share is lower-third: 0 of 64 reports (0.0% of named reports). Nearest volume peer: Preputial discharge (±0 reports). Lead species Dog (27). Lead co-reported drug Imidacloprid + Moxidectin (9).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Imidacloprid + Moxidectin appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 27
Cat 25
Human 10
Cattle 2

Breeds Most Affected

Domestic Shorthair 15
Unknown 11
Retriever - Labrador 5
Spitz - German Pomeranian 3
Domestic Longhair 3
Cat (unknown) 2
Chihuahua 2
Deutsche Dogge, Great Dane 2
Dog (other) 1
Pinscher - Miniature 1

Associated Drugs

Imidacloprid + Moxidectin 9
Emodepside + Praziquantel 5
Phenylpropanolamine Hcl 4
Buprenorphine 4
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 3
Milbemycin Oxime + Spinosad 3
Milbemycin Oxime + Praziquantel 3
Lotilaner 3
Maropitant Citrate 3
Imidacloprid And Moxidectin 2
Afoxolaner 2
Fluralaner Chew Tablets 2
Selamectin 2
Hyaluronic Acid 2
Cefovecin 2
Amoxicillin, Clavulanate Potassium 2
Ivermectin 2
Robenacoxib 2
Dexmedetomidine 2
Ketamine 2

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Lacrimation, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (64 here).

Similar death-coded share

Nearest other reactions by death-coded share (0.0% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Lacrimation (#1620 of 2,481 by report volume); death-coded 0.0%. PlainBreed reaction plate · death-coded share stamp 0.0% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →