Reaction profile

The FDA adverse-event record for dry mucous membrane

1,224 FDA reports name dry mucous membrane, a high-volume reaction in the CVM extract (VeDDRA 1210). Plate stamps and neighbourhood peers follow.

#335 of 2,481
by report volume (all reactions)
1,224
reports citing this reaction
22.6%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Dry mucous membrane has 1,224 reports now versus 1,195 in that prior snapshot: 29 more (2.4%).

Report change
+29
Death-coded reports
+4
Death-coded share
−0.2 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Dry mucous membrane changes

FDA AER · VeDDRA plate

Code 1210 VOL-MID

VOL-MID · DEATH-HOT · UPPER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 1,224 reports
  • DEATH-HOT 22.6%
  • UPPER-Q #335/2481
  • PHOTO-FINISH Hypersensitivity reac…
  • SPECIES-DOG Dog · 1,104
  • DRUG-LEAD Milbemycin Oxime… · 193
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Hypersensitivity reaction (±0 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Dry mucous membrane

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Pneumonia · near1230INEFFECTIVE, SEDATION · near1229Dry mucous membrane · this r…1224Hypersensitivity reac… · near1224Polypnoea · near1224Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Dry mucous membrane

What the FDA AER plate says about Dry mucous membrane

Signature read: 277 death-coded reports is a heavy tail count for Dry mucous membrane in the CVM extract. Report volume is upper-third scale: 1,224 named reports in the openFDA extract. 277 of 1,224 reports were death-coded (22.6% of named reports, not a population mortality rate). Nearest volume peer: Hypersensitivity reaction (±0 reports). Lead species Dog (1,104). Lead co-reported drug Milbemycin Oxime + Spinosad (193).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Milbemycin Oxime + Spinosad appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 1,104
Cat 106
Horse 14

Breeds Most Affected

Retriever - Labrador 109
Crossbred Canine/dog 76
Domestic Shorthair 74
Terrier - Yorkshire 55
Retriever - Golden 47
Shepherd Dog - German 38
Shih Tzu 38
Chihuahua 37
Dachshund (unspecified) 36
Boxer (German Boxer) 36

Associated Drugs

Milbemycin Oxime + Spinosad 193
Maropitant Citrate 158
Carprofen 151
Moxidectin 121
Gabapentin 65
Enrofloxacin 50
Buprenorphine 50
Spinosad 49
Fluralaner Chew Tablets 48
Afoxolaner 47
Metronidazole 46
Deracoxib 44
Trilostane 44
Famotidine 40
Bedinvetmab 40
Tramadol 39
Prednisone 39
Ivermectin + Pyrantel As Pamoate Salt 38
Oclacitinib Maleate 37
Rabies Vaccine 36

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Dry mucous membrane, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (1,224 here).

Similar death-coded share

Nearest other reactions by death-coded share (22.6% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Dry mucous membrane (#335 of 2,481 by report volume); death-coded 22.6%. PlainBreed reaction plate · death-coded report count stamp 277 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →