Reaction profile

The FDA adverse-event record for polydipsia

9,574 FDA reports name polydipsia, a high-volume reaction in the CVM extract (VeDDRA 543). Plate stamps and neighbourhood peers follow.

#48 of 2,481
by report volume (all reactions)
9,574
reports citing this reaction
11.6%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Polydipsia has 9,574 reports now versus 9,417 in that prior snapshot: 157 more (1.7%).

Report change
+157
Death-coded reports
+9
Death-coded share
−0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Polydipsia changes

FDA AER · VeDDRA plate

Code 543 VOL-HIGH

VOL-HIGH · DEATH-ELEV · TOP-DECILE · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-HIGH 9,574 reports
  • DEATH-ELEV 11.6%
  • TOP-DECILE #48/2481
  • PHOTO-FINISH Bloody diarrhoea
  • SPECIES-DOG Dog · 8,474
  • DRUG-LEAD Bedinvetmab · 1,620
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Bloody diarrhoea (±440 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Polydipsia

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Uncoded sign · near10179Elevated blood urea n… · near10167Bloody diarrhoea · near10014Polydipsia · this reaction9574Inappetence · near9069Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Polydipsia

What the FDA AER plate says about Polydipsia

Signature read: 1,114 death-coded reports is a heavy tail count for Polydipsia in the CVM extract. Report volume is upper-third scale: 9,574 named reports in the openFDA extract. 1,114 of 9,574 reports were death-coded (11.6% of named reports, not a population mortality rate). Nearest volume peer: Bloody diarrhoea (±440 reports). Lead species Dog (8,474). Lead co-reported drug Bedinvetmab (1,620).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Bedinvetmab appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 8,474
Cat 979
Horse 103
Cattle 7
Pig 2
Chicken 2
Cockatiel 2
Human 1
Monkey 1
Rabbit 1

Breeds Most Affected

Retriever - Labrador 1,011
Crossbred Canine/dog 699
Domestic Shorthair 557
Retriever - Golden 381
Shepherd Dog - German 335
Boxer (German Boxer) 278
Dog (unknown) 265
Chihuahua 217
Shih Tzu 200
Terrier - Yorkshire 190

Associated Drugs

Bedinvetmab 1,620
Trilostane 1,252
Carprofen 924
Oclacitinib Maleate 723
Prednisone 460
Gabapentin 420
Fluralaner Chew Tablets 364
Milbemycin Oxime + Spinosad 359
Maropitant Citrate 322
Afoxolaner 304
Pyrantel Pamoate;Sarolaner 257
Spinosad 237
Moxidectin 232
Meloxicam 218
Deracoxib 216
Bexagliflozin 201
Desoxycorticosterone Pivalate 193
Anti-Il31 Mab Mcs Lot #1283563 190
Grapiprant 189
Cyclosporine 182

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Polydipsia, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (9,574 here).

Similar death-coded share

Nearest other reactions by death-coded share (11.6% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Polydipsia (#48 of 2,481 by report volume); death-coded 11.6%. PlainBreed reaction plate · death-coded report count stamp 1,114 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →