Reaction profile

The FDA adverse-event record for bloody diarrhoea

9,714 FDA adverse-event reports reference bloody diarrhoea (VeDDRA 315). See the species, breeds, and drugs most associated with it below.

9,714
reports citing this reaction
10.8%
death-coded share
Dog
most-affected species
Carprofen
most-associated drug
Verify with FDA CVM →
9,714
Total Reports
1,051
Deaths
10.8%
Death Rate

Species Most Affected

Dog 9,244
Cat 362
Cattle 86
Horse 5
Chicken 3
Human 3
Pig 3
Ferret 2
Turkey 1
Goat 1

Breeds Most Affected

Retriever - Labrador 780
Crossbred Canine/dog 778
Terrier - Yorkshire 529
Chihuahua 431
Retriever - Golden 354
Dog (unknown) 297
Shih Tzu 286
Shepherd Dog - German 270
Beagle 232
Maltese 204

Associated Drugs

Carprofen 829
Milbemycin Oxime + Spinosad 814
Moxidectin 734
Afoxolaner 619
Maropitant Citrate 562
Ivermectin + Pyrantel As Pamoate Salt 524
Fluralaner Chew Tablets 471
Pyrantel Pamoate;Sarolaner 390
Grapiprant 384
Milbemycin Oxime + Praziquantel 306
Oclacitinib Maleate 293
Metronidazole 279
Spinosad 268
Meloxicam 255
Trilostane 254
Gabapentin 233
Melarsomine Dihydrochloride 218
Fluralaner 13.64% 12-Week Chew 212
Bedinvetmab 194
Sarolaner 192

Bloody diarrhoea Reaction Insights

9,714 reports name Bloody diarrhoea; 1,051 recorded a death outcome (10.8% of reported events, not a population-level mortality rate). VeDDRA code: 315.

By species: Dog (9,244 reports), Cat (362 reports), Cattle (86 reports). By breed: Retriever - Labrador (780), Crossbred Canine/dog (778), Terrier - Yorkshire (529).

Most co-reported drugs: Carprofen (829 reports), Milbemycin Oxime + Spinosad (814 reports), Moxidectin (734 reports), Afoxolaner (619 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.