Vaginal discharge

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VeDDRA Code: 1166

278 adverse event reports referencing this reaction

278
Total Reports
30
Deaths
1080.0%
Death Rate

Species Most Affected

Dog 249
Cattle 15
Cat 6
Goat 2
Horse 2
Hamster 2
Sheep 1
Pig 1

Breeds Most Affected

Retriever - Labrador 19
Crossbred Canine/dog 19
Shepherd Dog - German 13
Doberman Pinscher 11
Chihuahua 10
Pit Bull 8
Retriever - Golden 8
Poodle - Standard 6
Terrier - Bull - American Pit 6
Dog (unknown) 5

Associated Drugs

Estriol Tablets 74
Milbemycin Oxime + Spinosad 24
Bedinvetmab 19
Carprofen 18
Unspecified 17
Trilostane 15
Progesterone 14
Oclacitinib Maleate 14
Afoxolaner 13
Gabapentin 10
Amoxicillin 8
Grapiprant 8
Spinosad 7
Maropitant Citrate 7
Prednisone 7
Cefovecin 7
Milbemycin Oxime + Praziquantel 7
Fluralaner 13.64% 12-Week Chew 7
Doxycycline 6
Meloxicam 6

Data Summary

Metric Value
Total reports referencing reaction 278
Reports with fatal outcome 30
Case-fatality rate (reported events) 1080.0%
Species observed 8
Breeds observed 20
Drugs associated with reaction 20

Source: FDA Center for Veterinary Medicine — Adverse Event Reporting (CVM AER); reaction term coded under VeDDRA 1166.

Vaginal discharge Reaction Insights

The FDA Center for Veterinary Medicine database currently lists 278 adverse event reports that reference Vaginal discharge as a reaction term, including 30 reports with a death outcome — a 1080.0% case-fatality figure calculated across only those events where this reaction was coded. The reaction is indexed in the openFDA system under VeDDRA code 1166, the standardized veterinary dictionary used to normalize clinical signs across submitters. Because reports are voluntary and often describe multiple concurrent signs per animal, the volume here reflects reporting intensity rather than true incidence in the broader pet population.

Vaginal discharge appears most frequently in reports for Dog (249 reports), Cattle (15 reports), Cat (6 reports) — with Dog dominating at 249 entries. Within those species, the breeds most often named alongside this reaction are Retriever - Labrador (19), Crossbred Canine/dog (19), Shepherd Dog - German (13). These distributions are influenced both by underlying breed popularity and by how veterinarians and owners code a given clinical sign, so they should be interpreted as a reporting fingerprint rather than a pure susceptibility ranking.

The drugs most commonly co-reported with Vaginal discharge are Estriol Tablets (74 reports), Milbemycin Oxime + Spinosad (24 reports), Bedinvetmab (19 reports), Carprofen (18 reports), with Estriol Tablets appearing alongside this reaction in 74 submissions. Co-reporting does not establish that any specific product caused the reaction — FDA CVM data captures temporal association only. The value of these aggregates is in flagging which therapeutic classes appear repeatedly alongside a given clinical sign, so owners and veterinarians can ask targeted questions about medications currently in use.

Source: FDA Center for Veterinary Medicine — Adverse Event Reports FDA Center for Veterinary Medicine — Adverse Event Reports Data reflects voluntary submissions and may not represent actual incidence rates

Related

Data sourced from official AKC, AVMA, ACVO, and breed-club veterinary references. See our methodology for details. Retrieved and formatted by PlainBreed Editorial