Reaction profile

The FDA adverse-event record for vaginal discharge

278 FDA adverse-event reports reference vaginal discharge (VeDDRA 1166). See the species, breeds, and drugs most associated with it below.

278
reports citing this reaction
10.8%
death-coded share
Dog
most-affected species
Estriol Tablets
most-associated drug
Verify with FDA CVM →
278
Total Reports
30
Deaths
10.8%
Death Rate

Species Most Affected

Dog 249
Cattle 15
Cat 6
Goat 2
Horse 2
Hamster 2
Sheep 1
Pig 1

Breeds Most Affected

Retriever - Labrador 19
Crossbred Canine/dog 19
Shepherd Dog - German 13
Doberman Pinscher 11
Chihuahua 10
Pit Bull 8
Retriever - Golden 8
Poodle - Standard 6
Terrier - Bull - American Pit 6
Dog (unknown) 5

Associated Drugs

Estriol Tablets 74
Milbemycin Oxime + Spinosad 24
Bedinvetmab 19
Carprofen 18
Unspecified 17
Trilostane 15
Progesterone 14
Oclacitinib Maleate 14
Afoxolaner 13
Gabapentin 10
Amoxicillin 8
Grapiprant 8
Spinosad 7
Maropitant Citrate 7
Prednisone 7
Cefovecin 7
Milbemycin Oxime + Praziquantel 7
Fluralaner 13.64% 12-Week Chew 7
Doxycycline 6
Meloxicam 6

Vaginal discharge Reaction Insights

278 reports name Vaginal discharge; 30 recorded a death outcome (10.8% of reported events, not a population-level mortality rate). VeDDRA code: 1166.

By species: Dog (249 reports), Cattle (15 reports), Cat (6 reports). By breed: Retriever - Labrador (19), Crossbred Canine/dog (19), Shepherd Dog - German (13).

Most co-reported drugs: Estriol Tablets (74 reports), Milbemycin Oxime + Spinosad (24 reports), Bedinvetmab (19 reports), Carprofen (18 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.