Reaction profile

The FDA adverse-event record for eosinophilia

1,183 FDA reports name eosinophilia, a high-volume reaction in the CVM extract (VeDDRA 162). Plate stamps and neighbourhood peers follow.

#342 of 2,481
by report volume (all reactions)
1,183
reports citing this reaction
11.6%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Eosinophilia has 1,183 reports now versus 1,152 in that prior snapshot: 31 more (2.7%).

Report change
+31
Death-coded reports
+4
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Eosinophilia changes

FDA AER · VeDDRA plate

Code 162 VOL-MID

VOL-MID · DEATH-ELEV · UPPER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 1,183 reports
  • DEATH-ELEV 11.6%
  • UPPER-Q #342/2481
  • PHOTO-FINISH Melaena
  • SPECIES-DOG Dog · 899
  • DRUG-LEAD Milbemycin Oxime… · 132
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Melaena (±1 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Eosinophilia

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Hind limb paralysis · near1193Bone and joint disord… · near1189Eosinophilia · this reaction1183Melaena · near1182Musculoskeletal pain · near1177Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Eosinophilia

What the FDA AER plate says about Eosinophilia

Signature read: 1,183 reports place Eosinophilia in the upper third of FDA AER volume (#342 of 2,481). Report volume is upper-third scale: 1,183 named reports in the openFDA extract. 137 of 1,183 reports were death-coded (11.6% of named reports, not a population mortality rate). Nearest volume peer: Melaena (±1 reports). Lead species Dog (899). Lead co-reported drug Milbemycin Oxime + Spinosad (132).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Milbemycin Oxime + Spinosad appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 899
Cat 273
Horse 6
Cattle 2
Human 2
Ferret 1

Breeds Most Affected

Domestic Shorthair 158
Retriever - Labrador 118
Shepherd Dog - German 83
Crossbred Canine/dog 63
Retriever - Golden 37
Rottweiler 31
Chihuahua 30
Domestic Longhair 28
Pit Bull 26
Domestic Mediumhair 23

Associated Drugs

Milbemycin Oxime + Spinosad 132
Maropitant Citrate 76
Milbemycin Oxime + Praziquantel 74
Afoxolaner 73
Ivermectin + Pyrantel As Pamoate Salt 71
Fluralaner Chew Tablets 62
Carprofen 59
Spinosad 48
Oclacitinib Maleate 47
Moxidectin 43
Cefovecin 42
Selamectin 40
Lotilaner 39
Imidacloprid + Moxidectin 36
Doxycycline 35
Meloxicam 34
Prednisone 34
Gabapentin 33
Bedinvetmab 28
Pyrantel Pamoate;Sarolaner 27

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Eosinophilia, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (1,183 here).

Similar death-coded share

Nearest other reactions by death-coded share (11.6% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Eosinophilia (#342 of 2,481 by report volume); death-coded 11.6%. PlainBreed reaction plate · report volume stamp 1,183 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →