Reaction profile

The FDA adverse-event record for eosinophilia

1,105 FDA adverse-event reports reference eosinophilia (VeDDRA 162). See the species, breeds, and drugs most associated with it below.

1,105
reports citing this reaction
11.9%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
1,105
Total Reports
131
Deaths
11.9%
Death Rate

Species Most Affected

Dog 851
Cat 243
Horse 6
Cattle 2
Human 2
Ferret 1

Breeds Most Affected

Domestic Shorthair 136
Retriever - Labrador 113
Shepherd Dog - German 78
Crossbred Canine/dog 62
Retriever - Golden 34
Rottweiler 30
Domestic Longhair 27
Chihuahua 26
Pit Bull 24
Domestic Mediumhair 22

Associated Drugs

Milbemycin Oxime + Spinosad 131
Afoxolaner 71
Milbemycin Oxime + Praziquantel 69
Ivermectin + Pyrantel As Pamoate Salt 68
Fluralaner Chew Tablets 62
Maropitant Citrate 57
Carprofen 56
Spinosad 48
Oclacitinib Maleate 46
Moxidectin 39
Cefovecin 39
Selamectin 38
Imidacloprid + Moxidectin 35
Lotilaner 35
Meloxicam 32
Doxycycline 31
Prednisone 30
Gabapentin 29
Enrofloxacin 24
Milbemycin Oxime, Lufenuron 24

Eosinophilia Reaction Insights

1,105 reports name Eosinophilia; 131 recorded a death outcome (11.9% of reported events, not a population-level mortality rate). VeDDRA code: 162.

By species: Dog (851 reports), Cat (243 reports), Horse (6 reports). By breed: Domestic Shorthair (136), Retriever - Labrador (113), Shepherd Dog - German (78).

Most co-reported drugs: Milbemycin Oxime + Spinosad (131 reports), Afoxolaner (71 reports), Milbemycin Oxime + Praziquantel (69 reports), Ivermectin + Pyrantel As Pamoate Salt (68 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.