Reaction profile

The FDA adverse-event record for recovery prolonged

570 FDA adverse-event reports reference recovery prolonged (VeDDRA 1904). See the species, breeds, and drugs most associated with it below.

570
reports citing this reaction
16.0%
death-coded share
Dog
most-affected species
Isoflurane
most-associated drug
Verify with FDA CVM →
570
Total Reports
91
Deaths
16.0%
Death Rate

Species Most Affected

Dog 278
Cat 254
Horse 18
Pig 4
Mouse 3
Rabbit 2
Guinea Pig 2
Rat 1
Cattle 1
Other Mustelids 1

Breeds Most Affected

Domestic Shorthair 92
Dog (unknown) 65
Domestic (unspecified) 44
Cat (unknown) 34
Retriever - Labrador 30
Unknown 27
Domestic Longhair 21
Crossbred Canine/dog 15
Shih Tzu 13
Cat (other) 13

Associated Drugs

Isoflurane 144
Dexmedetomidine Hydrochloride 117
Propofol 89
Ketamine Hydrochloride 84
Butorphanol 80
Buprenorphine 72
Butorphanol Tartrate 61
Atipamezole Hydrochloride 53
Ketamine 50
Alfaxalone 38
Dexmedetomidine 37
Tiletamine Hcl; Zolazapam Hcl 31
Midazolam 30
Carprofen 29
Acepromazine Maleate 27
Meloxicam 26
Robenacoxib 23
Cefovecin 23
Atropine 21
Atipamezole 20

Recovery prolonged Reaction Insights

570 reports name Recovery prolonged; 91 recorded a death outcome (16.0% of reported events, not a population-level mortality rate). VeDDRA code: 1904.

By species: Dog (278 reports), Cat (254 reports), Horse (18 reports). By breed: Domestic Shorthair (92), Dog (unknown) (65), Domestic (unspecified) (44).

Most co-reported drugs: Isoflurane (144 reports), Dexmedetomidine Hydrochloride (117 reports), Propofol (89 reports), Ketamine Hydrochloride (84 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.