Reaction profile

The FDA adverse-event record for emesis (multiple)

18,161 FDA adverse-event reports reference emesis (multiple) (VeDDRA 2082). See the species, breeds, and drugs most associated with it below.

18,161
reports citing this reaction
5.1%
death-coded share
Dog
most-affected species
Fluralaner Chew Tablets
most-associated drug
Verify with FDA CVM →
18,161
Total Reports
925
Deaths
5.1%
Death Rate

Species Most Affected

Dog 15,996
Cat 2,140
Human 19
Unknown 2
Pig 2
Wolf 1
Dormouse 1

Breeds Most Affected

Crossbred Canine/dog 2,288
Retriever - Labrador 1,359
Domestic Shorthair 1,336
Chihuahua 802
Shih Tzu 681
Terrier - Yorkshire 679
Retriever - Golden 654
Shepherd Dog - German 478
Pit Bull 441
Dog (unknown) 375

Associated Drugs

Fluralaner Chew Tablets 3,130
Milbemycin Oxime + Spinosad 2,763
Fluralaner 13.64% 12-Week Chew 1,982
Spinosad 981
Pyrantel Pamoate;Sarolaner 880
Fluralaner Spot-On Solution 666
Febantel + Praziquantel + Pyrantel Pamoate 566
Ivermectin + Pyrantel As Pamoate Salt 534
Bedinvetmab 435
Afoxolaner 434
Maropitant Citrate 394
Moxidectin 393
Imidacloprid + Moxidectin 373
Fenbendazol Granules 342
Milbemycin Oxime + Praziquantel 340
Ivermectin + Pyrantel 330
Carprofen 286
Cyclosporine A 266
Oclacitinib Maleate 260
Nitenpyram 216

Emesis (multiple) Reaction Insights

18,161 reports name Emesis (multiple); 925 recorded a death outcome (5.1% of reported events, not a population-level mortality rate). VeDDRA code: 2082.

By species: Dog (15,996 reports), Cat (2,140 reports), Human (19 reports). By breed: Crossbred Canine/dog (2,288), Retriever - Labrador (1,359), Domestic Shorthair (1,336).

Most co-reported drugs: Fluralaner Chew Tablets (3,130 reports), Milbemycin Oxime + Spinosad (2,763 reports), Fluralaner 13.64% 12-Week Chew (1,982 reports), Spinosad (981 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.