Reaction profile

The FDA adverse-event record for prolonged anaesthesia

69 FDA adverse-event reports reference prolonged anaesthesia (VeDDRA 1218). See the species, breeds, and drugs most associated with it below.

69
reports citing this reaction
17.4%
death-coded share
Cat
most-affected species
Isoflurane
most-associated drug
Verify with FDA CVM →
69
Total Reports
12
Deaths
17.4%
Death Rate

Species Most Affected

Cat 33
Dog 27
Horse 4
Turtle 1
Other 1
Mouse 1
Rabbit 1
Donkey 1

Breeds Most Affected

Domestic Shorthair 18
Domestic (unspecified) 6
Unknown 6
Cat (unknown) 5
Crossbred Canine/dog 4
Dog (unknown) 4
Mixed (Dog) 2
Retriever - Labrador 2
Terrier - Yorkshire 2
Quarter Horse 2

Associated Drugs

Isoflurane 14
Butorphanol 14
Propofol 14
Buprenorphine 9
Alfaxalone 8
Ketamine 7
Dexmedetomidine Hydrochloride 6
Ketamine Hydrochloride 5
Dexmedetomidine 5
Device: Surgical Instruments 3
Xylazine 3
Robenacoxib 3
Atipamezole Hydrochloride 3
Fluralaner Chew Tablets 3
Butorphanol Tartrate 3
Oxygen 3
Tiletamine, Zolazepam 2
Acepromazine Maleate 2
Fentanyl 2
Tiletamine Hcl; Zolazapam Hcl 2

Prolonged anaesthesia Reaction Insights

69 reports name Prolonged anaesthesia; 12 recorded a death outcome (17.4% of reported events, not a population-level mortality rate). VeDDRA code: 1218.

By species: Cat (33 reports), Dog (27 reports), Horse (4 reports). By breed: Domestic Shorthair (18), Domestic (unspecified) (6), Unknown (6).

Most co-reported drugs: Isoflurane (14 reports), Butorphanol (14 reports), Propofol (14 reports), Buprenorphine (9 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.