Reaction profile

The FDA adverse-event record for grand mal seizure

942 FDA reports name grand mal seizure, a high-volume reaction in the CVM extract (VeDDRA 2727). Plate stamps and neighbourhood peers follow.

#411 of 2,481
by report volume (all reactions)
942
reports citing this reaction
16.9%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Grand mal seizure has 942 reports now versus 910 in that prior snapshot: 32 more (3.5%).

Report change
+32
Death-coded reports
+5
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Grand mal seizure changes

FDA AER · VeDDRA plate

Code 2727 VOL-MID

VOL-MID · DEATH-ELEV · UPPER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 942 reports
  • DEATH-ELEV 16.9%
  • UPPER-Q #411/2481
  • PHOTO-FINISH Urinary tract disorde…
  • SPECIES-DOG Dog · 857
  • DRUG-LEAD Pyrantel Pamoate;… · 151
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Urinary tract disorder NOS (±1 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Grand mal seizure

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Haematochezia · near948Respiratory tract dis… · near945Urinary tract disorde… · near943Grand mal seizure · this rea…942Drug administration d… · near938Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Grand mal seizure

What the FDA AER plate says about Grand mal seizure

Signature read: 159 death-coded reports is a heavy tail count for Grand mal seizure in the CVM extract. Report volume is upper-third scale: 942 named reports in the openFDA extract. 159 of 942 reports were death-coded (16.9% of named reports, not a population mortality rate). Nearest volume peer: Urinary tract disorder NOS (±1 reports). Lead species Dog (857). Lead co-reported drug Pyrantel Pamoate;Sarolaner (151).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Pyrantel Pamoate;Sarolaner appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 857
Cat 77
Horse 6
Ferret 1
Sheep 1

Breeds Most Affected

Retriever - Labrador 86
Crossbred Canine/dog 84
Retriever - Golden 59
Domestic Shorthair 55
Shepherd Dog - German 34
Shepherd Dog - Australian 34
Boxer (German Boxer) 29
Chihuahua 28
Terrier (unspecified) 24
Dog (unknown) 23

Associated Drugs

Pyrantel Pamoate;Sarolaner 151
Bedinvetmab 101
Sarolaner 100
Fluralaner 13.64% 12-Week Chew 98
Afoxolaner 89
Moxidectin 47
Fluralaner Chew Tablets 45
Gabapentin 36
Phenobarbital 30
Maropitant Citrate 30
Lotilaner 29
Oclacitinib Maleate 28
Carprofen 28
Ivermectin + Pyrantel As Pamoate Salt 24
Milbemycin Oxime + Praziquantel 23
Midazolam 21
Milbemycin Oxime 17
Levetiracetam 17
Meloxicam 16
Selamectin 16

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Grand mal seizure, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar death-coded share

Nearest other reactions by death-coded share (16.9% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Grand mal seizure (#411 of 2,481 by report volume); death-coded 16.9%. PlainBreed reaction plate · death-coded report count stamp 159 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →