Reaction profile

The FDA adverse-event record for grand mal seizure

875 FDA adverse-event reports reference grand mal seizure (VeDDRA 2727). See the species, breeds, and drugs most associated with it below.

875
reports citing this reaction
16.8%
death-coded share
Dog
most-affected species
Pyrantel Pamoate;Sarolaner
most-associated drug
Verify with FDA CVM →
875
Total Reports
147
Deaths
16.8%
Death Rate

Species Most Affected

Dog 801
Cat 67
Horse 5
Ferret 1
Sheep 1

Breeds Most Affected

Crossbred Canine/dog 83
Retriever - Labrador 77
Retriever - Golden 55
Domestic Shorthair 50
Shepherd Dog - Australian 31
Shepherd Dog - German 30
Boxer (German Boxer) 28
Chihuahua 26
Dog (unknown) 22
Terrier (unspecified) 21

Associated Drugs

Pyrantel Pamoate;Sarolaner 141
Sarolaner 96
Fluralaner 13.64% 12-Week Chew 94
Bedinvetmab 93
Afoxolaner 84
Fluralaner Chew Tablets 45
Moxidectin 44
Gabapentin 34
Maropitant Citrate 30
Phenobarbital 28
Carprofen 25
Ivermectin + Pyrantel As Pamoate Salt 24
Oclacitinib Maleate 24
Lotilaner 24
Milbemycin Oxime + Praziquantel 21
Midazolam 21
Milbemycin Oxime 17
Levetiracetam 17
Meloxicam 15
Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str 15

Grand mal seizure Reaction Insights

875 reports name Grand mal seizure; 147 recorded a death outcome (16.8% of reported events, not a population-level mortality rate). VeDDRA code: 2727.

By species: Dog (801 reports), Cat (67 reports), Horse (5 reports). By breed: Crossbred Canine/dog (83), Retriever - Labrador (77), Retriever - Golden (55).

Most co-reported drugs: Pyrantel Pamoate;Sarolaner (141 reports), Sarolaner (96 reports), Fluralaner 13.64% 12-Week Chew (94 reports), Bedinvetmab (93 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.