Reaction profile

The FDA adverse-event record for open mouth breathing

771 FDA adverse-event reports reference open mouth breathing (VeDDRA 1172). See the species, breeds, and drugs most associated with it below.

771
reports citing this reaction
25.3%
death-coded share
Cat
most-affected species
Cefovecin
most-associated drug
Verify with FDA CVM →
771
Total Reports
195
Deaths
25.3%
Death Rate

Species Most Affected

Cat 629
Dog 101
Cattle 27
Pig 4
Sheep 2
Horse 2
Chicken 2
Unknown 1
Llama 1
Goat 1

Breeds Most Affected

Domestic Shorthair 392
Domestic Longhair 68
Domestic Mediumhair 43
Cat (unknown) 27
Maine Coon 18
Cat (other) 17
Siamese 15
Chihuahua 14
Cattle (other) 9
Ragdoll 9

Associated Drugs

Cefovecin 83
Nitenpyram 78
Maropitant Citrate 59
Buprenorphine 53
Spinosad 51
Lotilaner 46
Fluralaner Spot-On Solution 40
Selamectin 39
Robenacoxib 38
Frunevetmab 31
Selamectin;Sarolaner 29
Butorphanol 25
Milbemycin Oxime + Spinosad 24
Rabies Vaccine 24
Ketamine 24
Dexamethasone 22
Fluralaner/Moxidectin Spot-On 22
Cefovecin Sodium 21
Methylprednisolone Acetate 20
Eprinomectin + Esafoxolaner + Praziquantel 20

Open mouth breathing Reaction Insights

771 reports name Open mouth breathing; 195 recorded a death outcome (25.3% of reported events, not a population-level mortality rate). VeDDRA code: 1172.

By species: Cat (629 reports), Dog (101 reports), Cattle (27 reports). By breed: Domestic Shorthair (392), Domestic Longhair (68), Domestic Mediumhair (43).

Most co-reported drugs: Cefovecin (83 reports), Nitenpyram (78 reports), Maropitant Citrate (59 reports), Buprenorphine (53 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.