Reaction profile

The FDA adverse-event record for open mouth breathing

812 FDA reports name open mouth breathing, a high-volume reaction in the CVM extract (VeDDRA 1172). Plate stamps and neighbourhood peers follow.

#456 of 2,481
by report volume (all reactions)
812
reports citing this reaction
24.9%
death-coded share
Cat
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Open mouth breathing has 812 reports now versus 791 in that prior snapshot: 21 more (2.7%).

Report change
+21
Death-coded reports
+4
Death-coded share
−0.2 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Open mouth breathing changes

FDA AER · VeDDRA plate

Code 1172 VOL-MID

VOL-MID · DEATH-HOT · UPPER-Q · PHOTO-FINISH · SPECIES-CAT · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 812 reports
  • DEATH-HOT 24.9%
  • UPPER-Q #456/2481
  • PHOTO-FINISH Neurological symptoms…
  • SPECIES-CAT Cat · 666
  • DRUG-LEAD Cefovecin · 89
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Neurological symptoms NOS (±1 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Open mouth breathing

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Neurological symptoms… · near813Open mouth breathing · this …812Distress · near809Haemorrhage NOS · near808Polyphagia · near806Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Open mouth breathing

Open mouth breathing: high death-coded share in the FDA AER plate

Signature read: 202 death-coded reports is a heavy tail count for Open mouth breathing in the CVM extract. Report volume is upper-third scale: 812 named reports in the openFDA extract. Death-coded share is upper-third: 202 of 812 reports (24.9% of named reports). Nearest volume peer: Neurological symptoms NOS (±1 reports). Lead species Cat (666). Lead co-reported drug Cefovecin (89).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Cat 666
Dog 105
Cattle 27
Pig 4
Sheep 2
Horse 2
Chicken 2
Unknown 1
Llama 1
Goat 1

Breeds Most Affected

Domestic Shorthair 413
Domestic Longhair 73
Domestic Mediumhair 46
Cat (unknown) 27
Maine Coon 19
Cat (other) 18
Siamese 16
Chihuahua 14
Ragdoll 11
Cattle (other) 9

Associated Drugs

Cefovecin 89
Nitenpyram 78
Maropitant Citrate 71
Buprenorphine 58
Spinosad 51
Lotilaner 49
Robenacoxib 46
Selamectin 41
Fluralaner Spot-On Solution 40
Frunevetmab 40
Selamectin;Sarolaner 32
Ketamine 26
Butorphanol 26
Rabies Vaccine 25
Milbemycin Oxime + Spinosad 24
Dexmedetomidine Hydrochloride 23
Fluralaner/Moxidectin Spot-On 23
Dexamethasone 22
Gabapentin 22
Eprinomectin + Esafoxolaner + Praziquantel 22

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Open mouth breathing, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (812 here).

Similar death-coded share

Nearest other reactions by death-coded share (24.9% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Open mouth breathing (#456 of 2,481 by report volume); death-coded 24.9%. PlainBreed reaction plate · death-coded report count stamp 202 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →