Reaction profile
The FDA adverse-event record for distress
809 FDA reports name distress, a high-volume reaction in the CVM extract (VeDDRA 114). Plate stamps and neighbourhood peers follow.
- #457 of 2,481
- by report volume (all reactions)
- 809
- reports citing this reaction
- 17.6%
- death-coded share
- Dog
- most-affected species
Release-over-release change
What changed in the latest FDA data snapshot
PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Distress has 809 reports now versus 789 in that prior snapshot: 20 more (2.5%).
- Report change
- +20
- Death-coded reports
- +0
- Death-coded share
- −0.4 pts
This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.
Subscribe to Distress changesFDA AER · VeDDRA plate
Code 114 VOL-MID
VOL-MID · DEATH-ELEV · UPPER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL
- VOL-MID 809 reports
- DEATH-ELEV 17.6%
- UPPER-Q #457/2481
- PHOTO-FINISH Haemorrhage NOS
- SPECIES-DOG Dog · 456
- DRUG-LEAD Milbemycin Oxime… · 64
- DESK-WIDE 20 breeds
- BOOK-FULL 8/8 fields
Nearest volume peer: Haemorrhage NOS (±1 reports)
Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.
High-volume neighbourhood around Distress
Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.
What the FDA AER plate says about Distress
Signature read: 142 death-coded reports is a heavy tail count for Distress in the CVM extract. Report volume is upper-third scale: 809 named reports in the openFDA extract. 142 of 809 reports were death-coded (17.6% of named reports, not a population mortality rate). Nearest volume peer: Haemorrhage NOS (±1 reports). Lead species Dog (456). Lead co-reported drug Milbemycin Oxime + Spinosad (64).
Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Milbemycin Oxime + Spinosad appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.
Species Most Affected
Breeds Most Affected
Associated Drugs
Nationwide reactions with similar profiles
Two openFDA-derived peer sets for Distress, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).
Similar report volume
Nearest other reactions by FDA report count (809 here).
Similar death-coded share
Nearest other reactions by death-coded share (17.6% here), distinct from the volume row.
What to do with this reaction
- Compare Distress's report profile against similar reactions nationwide. See similar reactions
- Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
- Browse the full reaction directory to compare report counts across reaction types. All reactions
A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.
Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025
Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →