Reaction profile

The FDA adverse-event record for anaphylactic shock

281 FDA adverse-event reports reference anaphylactic shock (VeDDRA 1112). See the species, breeds, and drugs most associated with it below.

281
reports citing this reaction
24.6%
death-coded share
Dog
most-affected species
Moxidectin
most-associated drug
Verify with FDA CVM →
281
Total Reports
69
Deaths
24.6%
Death Rate

Species Most Affected

Dog 226
Cat 24
Horse 14
Cattle 12
Pig 2
Human 2
Sheep 1

Breeds Most Affected

Domestic Shorthair 15
Chihuahua 15
Terrier - Bull - American Pit 13
Shih Tzu 11
Boxer (German Boxer) 11
Retriever - Labrador 10
Crossbred Canine/dog 10
Maltese 8
Dog (unknown) 8
Terrier - Yorkshire 8

Associated Drugs

Moxidectin 108
Maropitant Citrate 25
Cefovecin 20
Milbemycin Oxime + Spinosad 20
Dexamethasone 15
Diphenhydramine Hcl 15
Rabies Virus, Kv 12
Bordetella Bronchiseptica 92B 012992-7 Strain Boehringer Ingelheim 12
Rabies Virus, 12
Ivermectin + Pyrantel As Pamoate Salt 11
Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str 11
Carprofen 11
Famotidine 9
Melarsomine Dihydrochloride 8
Rabies Vaccine 6
Afoxolaner 6
Bedinvetmab 6
Epinephrine 5
Dexamethasone Sodium Phosphate 5
Melarsomine Dihydrochloride Injection 5

Anaphylactic shock Reaction Insights

281 reports name Anaphylactic shock; 69 recorded a death outcome (24.6% of reported events, not a population-level mortality rate). VeDDRA code: 1112.

By species: Dog (226 reports), Cat (24 reports), Horse (14 reports). By breed: Domestic Shorthair (15), Chihuahua (15), Terrier - Bull - American Pit (13).

Most co-reported drugs: Moxidectin (108 reports), Maropitant Citrate (25 reports), Cefovecin (20 reports), Milbemycin Oxime + Spinosad (20 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.