Reaction profile

The FDA adverse-event record for anaphylactic shock

293 FDA adverse-event reports reference anaphylactic shock (VeDDRA 1112). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#874 of 2,481
by report volume (all reactions)
293
reports citing this reaction
24.9%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Anaphylactic shock has 293 reports now versus 291 in that prior snapshot: 2 more (0.7%).

Report change
+2
Death-coded reports
+1
Death-coded share
+0.2 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Anaphylactic shock changes

FDA AER · VeDDRA plate

Code 1112 VOL-LOW

VOL-LOW · DEATH-HOT · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 293 reports
  • DEATH-HOT 24.9%
  • MID-PACK #874/2481
  • PHOTO-FINISH Bladder incontinence
  • SPECIES-DOG Dog · 234
  • DRUG-LEAD Moxidectin · 112
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Bladder incontinence (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Report-volume neighbourhood around Anaphylactic shock

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Abortion · near294Exercise intolerance · near294Anaphylactic shock · this re…293Bladder incontinence · near293Vaginal discharge · near293Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Anaphylactic shock

Anaphylactic shock: high death-coded share in the FDA AER plate

Signature read: 73 death-coded reports is a heavy tail count for Anaphylactic shock in the CVM extract. Report volume sits in the middle third of the reaction corpus. Death-coded share is upper-third: 73 of 293 reports (24.9% of named reports). Nearest volume peer: Bladder incontinence (±0 reports). Lead species Dog (234). Lead co-reported drug Moxidectin (112).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 234
Cat 28
Horse 14
Cattle 12
Pig 2
Human 2
Sheep 1

Breeds Most Affected

Domestic Shorthair 18
Chihuahua 15
Terrier - Bull - American Pit 14
Crossbred Canine/dog 12
Boxer (German Boxer) 12
Retriever - Labrador 11
Shih Tzu 11
Maltese 8
Dog (unknown) 8
Terrier - Yorkshire 8

Associated Drugs

Moxidectin 112
Maropitant Citrate 26
Cefovecin 22
Milbemycin Oxime + Spinosad 20
Dexamethasone 15
Diphenhydramine Hcl 15
Rabies Virus, Kv 13
Bordetella Bronchiseptica 92B 012992-7 Strain Boehringer Ingelheim 13
Rabies Virus, 12
Ivermectin + Pyrantel As Pamoate Salt 11
Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str 11
Carprofen 11
Famotidine 9
Melarsomine Dihydrochloride 9
Rabies Vaccine 7
Dexamethasone Sodium Phosphate 6
Diphenhydramine 6
Afoxolaner 6
Bedinvetmab 6
Epinephrine 5

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Anaphylactic shock, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (293 here).

Similar death-coded share

Nearest other reactions by death-coded share (24.9% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Anaphylactic shock (#874 of 2,481 by report volume); death-coded 24.9%. PlainBreed reaction plate · death-coded report count stamp 73 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →