Reaction profile

The FDA adverse-event record for flatulence, bloating and distension

116 FDA adverse-event reports reference flatulence, bloating and distension (VeDDRA 1477). See the species, breeds, and drugs most associated with it below.

116
reports citing this reaction
18.1%
death-coded share
Dog
most-affected species
Trilostane
most-associated drug
Verify with FDA CVM →
116
Total Reports
21
Deaths
18.1%
Death Rate

Species Most Affected

Dog 89
Cat 13
Horse 5
Cattle 5
Human 3
Unknown 1

Breeds Most Affected

Retriever - Labrador 13
Domestic Shorthair 5
Beagle 5
Shih Tzu 4
Unknown 4
Crossbred Canine/dog 4
Shepherd Dog - German 4
Cattle (unknown) 4
Boxer (German Boxer) 3
Terrier - Yorkshire 3

Associated Drugs

Trilostane 15
Carprofen 12
Milbemycin Oxime + Spinosad 9
Maropitant Citrate 8
Ivermectin + Pyrantel As Pamoate Salt 8
Fluralaner Chew Tablets 6
Metronidazole 5
Vaccines (Unknown) 5
Monensin Sodium 5
Afoxolaner 5
Ivermectin 5
Selamectin 4
Cefovecin 4
Famotidine 4
Milbemycin Oxime + Praziquantel 4
Lotilaner 4
Estradiol + Trenbolone Acetate + Tylosin Tartrate 4
Trenbolone; Estradiol; Tylosin Tartrate 4
Spinosad 3
Tramadol 3

Flatulence, bloating and distension Reaction Insights

116 reports name Flatulence, bloating and distension; 21 recorded a death outcome (18.1% of reported events, not a population-level mortality rate). VeDDRA code: 1477.

By species: Dog (89 reports), Cat (13 reports), Horse (5 reports). By breed: Retriever - Labrador (13), Domestic Shorthair (5), Beagle (5).

Most co-reported drugs: Trilostane (15 reports), Carprofen (12 reports), Milbemycin Oxime + Spinosad (9 reports), Maropitant Citrate (8 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.