Reaction profile

The FDA adverse-event record for neuromuscular disorder nos

185 FDA adverse-event reports reference neuromuscular disorder nos (VeDDRA 1649). See the species, breeds, and drugs most associated with it below.

185
reports citing this reaction
21.1%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
185
Total Reports
39
Deaths
21.1%
Death Rate

Species Most Affected

Dog 144
Cat 26
Turkey 7
Human 3
Chicken 2
Cattle 1
Pig 1
Horse 1

Breeds Most Affected

Domestic Shorthair 16
Retriever - Labrador 13
Boxer (German Boxer) 8
Turkey (unknown) 7
Chihuahua 6
Crossbred Canine/dog 6
Shepherd Dog - German 5
Pit Bull 5
Shih Tzu 5
Terrier (unspecified) 5

Associated Drugs

Milbemycin Oxime + Spinosad 39
Bedinvetmab 23
Sarolaner 13
Gabapentin 12
Carprofen 11
Monensin Sodium 8
Oclacitinib Maleate 8
Spinosad 7
Moxidectin 7
Selamectin 6
Fluralaner Chew Tablets 6
Rabies Vaccine 5
Nitenpyram 5
Ivermectin + Pyrantel As Pamoate Salt 5
Cefovecin 5
Tramadol 5
Grapiprant 5
Afoxolaner 4
Prednisone 4
Isoflurane 4

Neuromuscular disorder NOS Reaction Insights

185 reports name Neuromuscular disorder NOS; 39 recorded a death outcome (21.1% of reported events, not a population-level mortality rate). VeDDRA code: 1649.

By species: Dog (144 reports), Cat (26 reports), Turkey (7 reports). By breed: Domestic Shorthair (16), Retriever - Labrador (13), Boxer (German Boxer) (8).

Most co-reported drugs: Milbemycin Oxime + Spinosad (39 reports), Bedinvetmab (23 reports), Sarolaner (13 reports), Gabapentin (12 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.