Reaction profile

The FDA adverse-event record for cutaneous calcinosis

177 FDA adverse-event reports reference cutaneous calcinosis (VeDDRA 2079). See the species, breeds, and drugs most associated with it below.

177
reports citing this reaction
13.6%
death-coded share
Dog
most-affected species
Trilostane
most-associated drug
Verify with FDA CVM →
177
Total Reports
24
Deaths
13.6%
Death Rate

Species Most Affected

Dog 176
Cat 1

Breeds Most Affected

Terrier - Boston 27
Bulldog - French 17
Bulldog 12
Boxer (German Boxer) 10
Retriever - Labrador 9
Chihuahua 8
American Pit Bull Terrier 7
Maltese 6
Dog (unknown) 6
Dachshund - Miniature 5

Associated Drugs

Trilostane 213
Oclacitinib Maleate 17
Prednisone 14
Cefpodoxime Proxetil 7
Oclacitinib 6
Cyclosporine 6
Cyclosporine A 5
Enrofloxacin 5
Tramadol 4
Ivermectin 4
Ketoconazole 4
Selamectin 4
Cefpodoxime 4
Anti-Il31 Mab Mcs Lot #1283563 4
Triamcinolone Acetonide 0.015% 3
Gabapentin 3
Cefovecin 3
Doxycycline 3
Ursodiol 3
Diphenhydramine 3

Cutaneous calcinosis Reaction Insights

177 reports name Cutaneous calcinosis; 24 recorded a death outcome (13.6% of reported events, not a population-level mortality rate). VeDDRA code: 2079.

By species: Dog (176 reports), Cat (1 reports). By breed: Terrier - Boston (27), Bulldog - French (17), Bulldog (12).

Most co-reported drugs: Trilostane (213 reports), Oclacitinib Maleate (17 reports), Prednisone (14 reports), Cefpodoxime Proxetil (7 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.