Reaction profile

The FDA adverse-event record for walking difficulty

4,808 FDA reports name walking difficulty, a high-volume reaction in the CVM extract (VeDDRA 1902). Plate stamps and neighbourhood peers follow.

#101 of 2,481
by report volume (all reactions)
4,808
reports citing this reaction
21.4%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Walking difficulty has 4,808 reports now versus 4,739 in that prior snapshot: 69 more (1.5%).

Report change
+69
Death-coded reports
+18
Death-coded share
+0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Walking difficulty changes

FDA AER · VeDDRA plate

Code 1902 VOL-MID

VOL-MID · DEATH-HOT · TOP-DECILE · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 4,808 reports
  • DEATH-HOT 21.4%
  • TOP-DECILE #101/2481
  • PHOTO-FINISH Underfilling, Tubes
  • SPECIES-DOG Dog · 4,033
  • DRUG-LEAD Milbemycin Oxime… · 632
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Underfilling, Tubes (±0 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Walking difficulty

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Abnormal ultrasound f… · near4860Deafness · near4836Appearance, Abnormal · near4824Underfilling, Tubes · near4808Walking difficulty · this re…4808Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Walking difficulty

What the FDA AER plate says about Walking difficulty

Signature read: 1,031 death-coded reports is a heavy tail count for Walking difficulty in the CVM extract. Report volume is upper-third scale: 4,808 named reports in the openFDA extract. 1,031 of 4,808 reports were death-coded (21.4% of named reports, not a population mortality rate). Nearest volume peer: Underfilling, Tubes (±0 reports). Lead species Dog (4,033). Lead co-reported drug Milbemycin Oxime + Spinosad (632).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Milbemycin Oxime + Spinosad appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 4,033
Cat 716
Cattle 22
Horse 21
Human 5
Sheep 2
Goat 2
Other Canids 1
Rabbit 1
Pig 1

Breeds Most Affected

Retriever - Labrador 453
Domestic Shorthair 432
Crossbred Canine/dog 268
Chihuahua 202
Shepherd Dog - German 176
Retriever - Golden 169
Dog (unknown) 152
Terrier - Yorkshire 130
Shih Tzu 127
Boxer (German Boxer) 106

Associated Drugs

Milbemycin Oxime + Spinosad 632
Bedinvetmab 502
Carprofen 379
Afoxolaner 344
Gabapentin 260
Maropitant Citrate 199
Pyrantel Pamoate;Sarolaner 199
Fluralaner 13.64% 12-Week Chew 190
Spinosad 179
Ivermectin + Pyrantel As Pamoate Salt 171
Sarolaner 169
Fluralaner Chew Tablets 163
Cefovecin 162
Oclacitinib Maleate 151
Moxidectin 148
Prednisone 145
Selamectin 139
Trilostane 124
Milbemycin Oxime + Praziquantel 107
Frunevetmab 102

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Walking difficulty, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (4,808 here).

Similar death-coded share

Nearest other reactions by death-coded share (21.4% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Walking difficulty (#101 of 2,481 by report volume); death-coded 21.4%. PlainBreed reaction plate · death-coded report count stamp 1,031 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →