Reaction profile

The FDA adverse-event record for walking difficulty

4,623 FDA adverse-event reports reference walking difficulty (VeDDRA 1902). See the species, breeds, and drugs most associated with it below.

4,623
reports citing this reaction
21.2%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
4,623
Total Reports
981
Deaths
21.2%
Death Rate

Species Most Affected

Dog 3,892
Cat 674
Horse 21
Cattle 20
Human 5
Goat 2
Sheep 2
Other Canids 1
Rabbit 1
Pig 1

Breeds Most Affected

Retriever - Labrador 426
Domestic Shorthair 407
Crossbred Canine/dog 256
Chihuahua 199
Shepherd Dog - German 172
Retriever - Golden 162
Dog (unknown) 146
Terrier - Yorkshire 126
Shih Tzu 124
Boxer (German Boxer) 102

Associated Drugs

Milbemycin Oxime + Spinosad 629
Bedinvetmab 439
Carprofen 357
Afoxolaner 337
Gabapentin 234
Maropitant Citrate 190
Pyrantel Pamoate;Sarolaner 185
Fluralaner 13.64% 12-Week Chew 184
Spinosad 179
Ivermectin + Pyrantel As Pamoate Salt 168
Sarolaner 165
Fluralaner Chew Tablets 163
Cefovecin 159
Moxidectin 143
Oclacitinib Maleate 142
Selamectin 136
Prednisone 135
Trilostane 119
Milbemycin Oxime + Praziquantel 103
Grapiprant 87

Walking difficulty Reaction Insights

4,623 reports name Walking difficulty; 981 recorded a death outcome (21.2% of reported events, not a population-level mortality rate). VeDDRA code: 1902.

By species: Dog (3,892 reports), Cat (674 reports), Horse (21 reports). By breed: Retriever - Labrador (426), Domestic Shorthair (407), Crossbred Canine/dog (256).

Most co-reported drugs: Milbemycin Oxime + Spinosad (629 reports), Bedinvetmab (439 reports), Carprofen (357 reports), Afoxolaner (337 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.