Reaction profile

The FDA adverse-event record for murmur

295 FDA adverse-event reports reference murmur (VeDDRA 214). See the species, breeds, and drugs most associated with it below.

295
reports citing this reaction
32.2%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
295
Total Reports
95
Deaths
32.2%
Death Rate

Species Most Affected

Dog 215
Cat 72
Horse 8

Breeds Most Affected

Domestic (unspecified) 37
Crossbred Canine/dog 27
Chihuahua 21
Shih Tzu 16
Domestic Shorthair 12
Spaniel - Cocker American 11
Dog (unknown) 11
Cat (unknown) 10
Dachshund (unspecified) 10
Retriever - Labrador 8

Associated Drugs

Milbemycin Oxime + Spinosad 30
Spinosad 23
Cefovecin Sodium 17
Carprofen 16
Melarsomine Dihydrochloride 15
Dexmedetomidine Hydrochloride 14
Meloxicam 12
Trilostane 11
Selamectin 10
Moxidectin 9
Maropitant 7
Cyclosporine 7
Atipamezole 7
Amoxicillin, Clavulanate 6
Deracoxib 6
Fluralaner Chew Tablets 6
Isoflurane 5
Propofol 5
Dirlotapide 5
Pimobendan 4

Murmur Reaction Insights

295 reports name Murmur; 95 recorded a death outcome (32.2% of reported events, not a population-level mortality rate). VeDDRA code: 214.

By species: Dog (215 reports), Cat (72 reports), Horse (8 reports). By breed: Domestic (unspecified) (37), Crossbred Canine/dog (27), Chihuahua (21).

Most co-reported drugs: Milbemycin Oxime + Spinosad (30 reports), Spinosad (23 reports), Cefovecin Sodium (17 reports), Carprofen (16 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.