Reaction profile

The FDA adverse-event record for murmur

Name: Murmur - FDA Animal Adverse Reaction
Creator: PlainBreed
License: https://open.fda.gov/license/

300 FDA adverse-event reports reference murmur (VeDDRA 214). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#867 of 2,481
by report volume (all reactions): 300
reports citing this reaction: 31.7%
death-coded share: Dog
most-affected species

Compiled by PlainBreed

Verify with FDA CVM →

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Murmur has 300 reports now versus 298 in that prior snapshot: 2 more (0.7%).

Report change: +2
Death-coded reports: +0
Death-coded share: −0.2 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Murmur changes

FDA AER · VeDDRA plate

Code 214 VOL-LOW

VOL-LOW · DEATH-HOT · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

VOL-LOW 300 reports
DEATH-HOT 31.7%
MID-PACK #867/2481
PHOTO-FINISH Lack of efficacy (ect…
SPECIES-DOG Dog · 216
DRUG-LEAD Milbemycin Oxime… · 30
DESK-WIDE 20 breeds
BOOK-FULL 8/8 fields

Nearest volume peer: Lack of efficacy (ectoparasite) - Sarcoptes (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Report-volume neighbourhood around Murmur

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

FDA AER report volume · neighbourhood around Murmur

Murmur: high death-coded share in the FDA AER plate

Signature read: 95 death-coded reports is a heavy tail count for Murmur in the CVM extract. Report volume sits in the middle third of the reaction corpus. Death-coded share is upper-third: 95 of 300 reports (31.7% of named reports). Nearest volume peer: Lack of efficacy (ectoparasite) - Sarcoptes (±0 reports). Lead species Dog (216). Lead co-reported drug Milbemycin Oxime + Spinosad (30).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 216

Cat 76

Horse 8

Breeds Most Affected

Domestic (unspecified) 37

Crossbred Canine/dog 27

Chihuahua 21

Shih Tzu 16

Domestic Shorthair 15

Spaniel - Cocker American 11

Dog (unknown) 11

Cat (unknown) 10

Dachshund (unspecified) 10

Retriever - Labrador 8

Associated Drugs

Milbemycin Oxime + Spinosad 30

Spinosad 23

Cefovecin Sodium 17

Carprofen 16

Melarsomine Dihydrochloride 15

Dexmedetomidine Hydrochloride 15

Meloxicam 12

Trilostane 11

Selamectin 10

Moxidectin 9

Maropitant 8

Propofol 7

Cyclosporine 7

Atipamezole 7

Isoflurane 6

Amoxicillin, Clavulanate 6

Deracoxib 6

Fluralaner Chew Tablets 6

Dirlotapide 5

Butorphanol Tartrate 5

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Murmur, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (300 here).

Lack of efficacy (ectoparasite) - Sarcoptes 300 Swallowing difficult 300 Elevated pancreatic enzymes 302 Injection site complication NOS 302

Similar death-coded share

Nearest other reactions by death-coded share (31.7% here), distinct from the volume row.

Elevated renal parameters 31.7% Adrenal gland disorder NOS 31.7% Pharyngeal oedema 31.6% Prostatic disorder NOS 31.6%

What to do with this reaction

Compare Murmur's report profile against similar reactions nationwide. See similar reactions
Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
Browse the full reaction directory to compare report counts across reaction types. All reactions

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Murmur (#867 of 2,481 by report volume); death-coded 31.7%. PlainBreed reaction plate · death-coded report count stamp 95 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →