Reaction profile

The FDA adverse-event record for adrenal gland disorder nos

556 FDA adverse-event reports reference adrenal gland disorder nos (VeDDRA 378). See the species, breeds, and drugs most associated with it below.

556
reports citing this reaction
31.7%
death-coded share
Dog
most-affected species
Trilostane
most-associated drug
Verify with FDA CVM →
556
Total Reports
176
Deaths
31.7%
Death Rate

Species Most Affected

Dog 531
Cat 17
Horse 4
Ferret 3
Other Birds 1

Breeds Most Affected

Retriever - Labrador 65
Crossbred Canine/dog 35
Chihuahua 26
Maltese 20
Beagle 20
Dog (unknown) 18
Boxer (German Boxer) 17
Shih Tzu 17
Terrier - Boston 16
Retriever - Golden 14

Associated Drugs

Trilostane 305
Carprofen 58
Maropitant Citrate 42
Bedinvetmab 39
Milbemycin Oxime + Spinosad 36
Oclacitinib Maleate 33
Gabapentin 30
Grapiprant 28
Tramadol 20
Fluralaner Chew Tablets 20
Metronidazole 18
Insulin Injectable Vial 18
Spinosad 16
Prednisone 16
Afoxolaner 16
Polysulfated Glycosaminoglycan 15
Anti-Il31 Mab Mcs Lot #1283563 12
Moxidectin 12
Famotidine 12
Levothyroxine 12

Adrenal gland disorder NOS Reaction Insights

556 reports name Adrenal gland disorder NOS; 176 recorded a death outcome (31.7% of reported events, not a population-level mortality rate). VeDDRA code: 378.

By species: Dog (531 reports), Cat (17 reports), Horse (4 reports). By breed: Retriever - Labrador (65), Crossbred Canine/dog (35), Chihuahua (26).

Most co-reported drugs: Trilostane (305 reports), Carprofen (58 reports), Maropitant Citrate (42 reports), Bedinvetmab (39 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.