Reaction profile

The FDA adverse-event record for elevated renal parameters

1,879 FDA adverse-event reports reference elevated renal parameters (VeDDRA 1992). See the species, breeds, and drugs most associated with it below.

1,879
reports citing this reaction
31.2%
death-coded share
Dog
most-affected species
Carprofen
most-associated drug
Verify with FDA CVM →
1,879
Total Reports
587
Deaths
31.2%
Death Rate

Species Most Affected

Dog 1,474
Cat 387
Horse 15
Rabbit 1
Sheep 1
Goat 1

Breeds Most Affected

Retriever - Labrador 211
Domestic Shorthair 204
Crossbred Canine/dog 72
Retriever - Golden 62
Chihuahua 59
Terrier - Yorkshire 55
Dog (unknown) 46
Shepherd Dog - German 45
Shih Tzu 44
Beagle 40

Associated Drugs

Carprofen 374
Maropitant Citrate 263
Bedinvetmab 215
Trilostane 153
Oclacitinib Maleate 146
Grapiprant 104
Gabapentin 102
Cefovecin 98
Famotidine 92
Meloxicam 88
Frunevetmab 84
Moxidectin 78
Milbemycin Oxime + Spinosad 70
Tramadol 69
Deracoxib 65
Enrofloxacin 50
Buprenorphine 44
Prednisone 43
Metronidazole 42
Doxycycline 41

Elevated renal parameters Reaction Insights

1,879 reports name Elevated renal parameters; 587 recorded a death outcome (31.2% of reported events, not a population-level mortality rate). VeDDRA code: 1992.

By species: Dog (1,474 reports), Cat (387 reports), Horse (15 reports). By breed: Retriever - Labrador (211), Domestic Shorthair (204), Crossbred Canine/dog (72).

Most co-reported drugs: Carprofen (374 reports), Maropitant Citrate (263 reports), Bedinvetmab (215 reports), Trilostane (153 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.