Reaction profile

The FDA adverse-event record for melanoma

121 FDA adverse-event reports reference melanoma (VeDDRA 918). See the species, breeds, and drugs most associated with it below.

121
reports citing this reaction
24.8%
death-coded share
Dog
most-affected species
Oclacitinib Maleate
most-associated drug
Verify with FDA CVM →
121
Total Reports
30
Deaths
24.8%
Death Rate

Species Most Affected

Dog 117
Horse 2
Cat 2

Breeds Most Affected

Retriever - Labrador 18
Dog (unknown) 10
Crossbred Canine/dog 9
Shepherd Dog - German 9
Retriever - Golden 6
Spaniel - Cocker American 4
Rottweiler 4
Terrier - Bull - American Pit 3
Pit Bull 3
Beagle 3

Associated Drugs

Oclacitinib Maleate 63
Milbemycin Oxime + Spinosad 8
Milbemycin Oxime + Praziquantel 8
Gabapentin 6
Cyclosporine A 5
Anti-Il31 Mab Mcs Lot #1283563 5
Trilostane 5
Bedinvetmab 5
Cyclosporine 4
Fluralaner 13.64% 12-Week Chew 4
Melanoma Vaccine 3
Imidacloprid + Moxidectin 3
Carprofen 3
Afoxolaner 3
Selamectin 3
Tramadol 2
Fish Oil 2
Ketoconazole 2
Cephalexin 2
Unknown If Concomitant Medications 2

Melanoma Reaction Insights

121 reports name Melanoma; 30 recorded a death outcome (24.8% of reported events, not a population-level mortality rate). VeDDRA code: 918.

By species: Dog (117 reports), Horse (2 reports), Cat (2 reports). By breed: Retriever - Labrador (18), Dog (unknown) (10), Crossbred Canine/dog (9).

Most co-reported drugs: Oclacitinib Maleate (63 reports), Milbemycin Oxime + Spinosad (8 reports), Milbemycin Oxime + Praziquantel (8 reports), Gabapentin (6 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.