Reaction profile

The FDA adverse-event record for low pancreatic enzymes

121 FDA adverse-event reports reference low pancreatic enzymes (VeDDRA 2694). See the species, breeds, and drugs most associated with it below.

121
reports citing this reaction
19.0%
death-coded share
Dog
most-affected species
Fluralaner 13.64% 12-Week Chew
most-associated drug
Verify with FDA CVM →
121
Total Reports
23
Deaths
19.0%
Death Rate

Species Most Affected

Dog 101
Cat 20

Breeds Most Affected

Crossbred Canine/dog 15
Domestic Shorthair 13
Siberian Husky 8
Chihuahua 7
Terrier - Yorkshire 7
Shih Tzu 6
Shepherd Dog - German 6
Retriever - Labrador 4
Pointing Dog - German Short-haired 4
Retriever - Golden 4

Associated Drugs

Fluralaner 13.64% 12-Week Chew 21
Gabapentin 15
Afoxolaner 12
Maropitant Citrate 12
Carprofen 10
Doxycycline 9
Bexagliflozin 9
Metronidazole 8
Oclacitinib Maleate 7
Propofol 7
Enrofloxacin 7
Meloxicam 7
Milbemycin Oxime + Praziquantel 7
Dexmedetomidine 7
Dexamethasone Sodium Phosphate 6
Maropitant 6
Buprenorphine 6
Milbemycin/Lufenuron/Pzq Chew 6
Prednisone 6
Lidocaine 6

Low pancreatic enzymes Reaction Insights

121 reports name Low pancreatic enzymes; 23 recorded a death outcome (19.0% of reported events, not a population-level mortality rate). VeDDRA code: 2694.

By species: Dog (101 reports), Cat (20 reports). By breed: Crossbred Canine/dog (15), Domestic Shorthair (13), Siberian Husky (8).

Most co-reported drugs: Fluralaner 13.64% 12-Week Chew (21 reports), Gabapentin (15 reports), Afoxolaner (12 reports), Maropitant Citrate (12 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.