Reaction profile

The FDA adverse-event record for reduced globulins

635 FDA adverse-event reports reference reduced globulins (VeDDRA 2557). See the species, breeds, and drugs most associated with it below.

635
reports citing this reaction
23.9%
death-coded share
Dog
most-affected species
Carprofen
most-associated drug
Verify with FDA CVM →
635
Total Reports
152
Deaths
23.9%
Death Rate

Species Most Affected

Dog 590
Cat 35
Horse 9
Cattle 1

Breeds Most Affected

Retriever - Labrador 93
Crossbred Canine/dog 40
Retriever - Golden 39
Terrier - Yorkshire 24
Chihuahua 21
Domestic Shorthair 20
Shih Tzu 18
Pit Bull 14
Dachshund (unspecified) 14
Shepherd Dog - Australian 14

Associated Drugs

Carprofen 91
Oclacitinib Maleate 89
Maropitant Citrate 57
Afoxolaner 57
Moxidectin 36
Milbemycin Oxime + Spinosad 35
Ivermectin + Pyrantel As Pamoate Salt 34
Metronidazole 25
Gabapentin 25
Fluralaner Chew Tablets 25
Deracoxib 24
Pyrantel Pamoate;Sarolaner 23
Maropitant 21
Prednisone 21
Trilostane 20
Famotidine 20
Grapiprant 18
Enrofloxacin 17
Spinosad 15
Buprenorphine 15

Reduced globulins Reaction Insights

635 reports name Reduced globulins; 152 recorded a death outcome (23.9% of reported events, not a population-level mortality rate). VeDDRA code: 2557.

By species: Dog (590 reports), Cat (35 reports), Horse (9 reports). By breed: Retriever - Labrador (93), Crossbred Canine/dog (40), Retriever - Golden (39).

Most co-reported drugs: Carprofen (91 reports), Oclacitinib Maleate (89 reports), Maropitant Citrate (57 reports), Afoxolaner (57 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.