Reaction profile

The FDA adverse-event record for balance problem

1,064 FDA adverse-event reports reference balance problem (VeDDRA 372). See the species, breeds, and drugs most associated with it below.

1,064
reports citing this reaction
10.1%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
1,064
Total Reports
107
Deaths
10.1%
Death Rate

Species Most Affected

Dog 833
Cat 158
Human 59
Horse 9
Cattle 3
Fish 1
Sheep 1

Breeds Most Affected

Domestic Shorthair 99
Retriever - Labrador 68
Unknown 60
Crossbred Canine/dog 56
Chihuahua 47
Terrier - Yorkshire 36
Boxer (German Boxer) 35
Dog (unknown) 34
Retriever - Golden 32
Maltese 22

Associated Drugs

Milbemycin Oxime + Spinosad 104
Carprofen 77
Afoxolaner 75
Bedinvetmab 64
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 60
Pyrantel Pamoate;Sarolaner 45
Spinosad 43
Fluralaner 13.64% 12-Week Chew 41
Fluralaner Chew Tablets 37
Sarolaner 37
Trilostane 30
Gabapentin 30
Maropitant Citrate 29
Selamectin 28
Ivermectin + Pyrantel As Pamoate Salt 24
Lotilaner 23
Milbemycin Oxime + Praziquantel 22
Prednisone 21
Moxidectin 21
Ivermectin 18

Balance problem Reaction Insights

1,064 reports name Balance problem; 107 recorded a death outcome (10.1% of reported events, not a population-level mortality rate). VeDDRA code: 372.

By species: Dog (833 reports), Cat (158 reports), Human (59 reports). By breed: Domestic Shorthair (99), Retriever - Labrador (68), Unknown (60).

Most co-reported drugs: Milbemycin Oxime + Spinosad (104 reports), Carprofen (77 reports), Afoxolaner (75 reports), Bedinvetmab (64 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.