Inappropriate schedule of drug administration

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VeDDRA Code: 99832

1,075 adverse event reports referencing this reaction

1,075
Total Reports
23
Deaths
210.0%
Death Rate

Species Most Affected

Dog 994
Cat 41
Horse 24
Cattle 11
Sheep 2
Pig 1
Goat 1
Mouse 1

Breeds Most Affected

Retriever - Labrador 84
Dog (unknown) 48
Terrier - Yorkshire 47
Crossbred Canine/dog 44
Shih Tzu 43
Chihuahua 40
Retriever - Golden 40
Shepherd Dog - German 38
Terrier - Bull - American Pit 30
Maltese 30

Associated Drugs

Oclacitinib Maleate 587
Anti-Il31 Mab Mcs Lot #1283563 137
Trilostane 106
Polysulfated Glycosaminoglycan 44
Melarsomine Dihydrochloride 34
Milbemycin Oxime + Spinosad 32
Prednisone 24
Ivermectin + Pyrantel As Pamoate Salt 23
Afoxolaner 21
Moxidectin 21
Fluralaner 13.64% 12-Week Chew 19
Gabapentin 18
Carprofen 16
Milbemycin Oxime + Praziquantel 16
Fluralaner Chew Tablets 14
Selamectin 13
Diphenhydramine Hcl 13
Spinosad 13
Cefpodoxime Proxetil 12
Cefovecin 11

Data Summary

Metric Value
Total reports referencing reaction 1,075
Reports with fatal outcome 23
Case-fatality rate (reported events) 210.0%
Species observed 8
Breeds observed 20
Drugs associated with reaction 20

Source: FDA Center for Veterinary Medicine — Adverse Event Reporting (CVM AER); reaction term coded under VeDDRA 99832.

Inappropriate schedule of drug administration Reaction Insights

The FDA Center for Veterinary Medicine database currently lists 1,075 adverse event reports that reference Inappropriate schedule of drug administration as a reaction term, including 23 reports with a death outcome — a 210.0% case-fatality figure calculated across only those events where this reaction was coded. The reaction is indexed in the openFDA system under VeDDRA code 99832, the standardized veterinary dictionary used to normalize clinical signs across submitters. Because reports are voluntary and often describe multiple concurrent signs per animal, the volume here reflects reporting intensity rather than true incidence in the broader pet population.

Inappropriate schedule of drug administration appears most frequently in reports for Dog (994 reports), Cat (41 reports), Horse (24 reports) — with Dog dominating at 994 entries. Within those species, the breeds most often named alongside this reaction are Retriever - Labrador (84), Dog (unknown) (48), Terrier - Yorkshire (47). These distributions are influenced both by underlying breed popularity and by how veterinarians and owners code a given clinical sign, so they should be interpreted as a reporting fingerprint rather than a pure susceptibility ranking.

The drugs most commonly co-reported with Inappropriate schedule of drug administration are Oclacitinib Maleate (587 reports), Anti-Il31 Mab Mcs Lot #1283563 (137 reports), Trilostane (106 reports), Polysulfated Glycosaminoglycan (44 reports), with Oclacitinib Maleate appearing alongside this reaction in 587 submissions. Co-reporting does not establish that any specific product caused the reaction — FDA CVM data captures temporal association only. The value of these aggregates is in flagging which therapeutic classes appear repeatedly alongside a given clinical sign, so owners and veterinarians can ask targeted questions about medications currently in use.

Source: FDA Center for Veterinary Medicine — Adverse Event Reports FDA Center for Veterinary Medicine — Adverse Event Reports Data reflects voluntary submissions and may not represent actual incidence rates

Related

Data sourced from official AKC, AVMA, ACVO, and breed-club veterinary references. See our methodology for details. Retrieved and formatted by PlainBreed Editorial