Reaction profile

The FDA adverse-event record for temporary blindness

440 FDA adverse-event reports reference temporary blindness (VeDDRA 1829). See the species, breeds, and drugs most associated with it below.

440
reports citing this reaction
7.5%
death-coded share
Dog
most-affected species
Ivermectin
most-associated drug
Verify with FDA CVM →
440
Total Reports
33
Deaths
7.5%
Death Rate

Species Most Affected

Dog 331
Cat 74
Cattle 23
Horse 7
Human 4
Other Deer 1

Breeds Most Affected

Retriever - Labrador 29
Crossbred Canine/dog 27
Domestic Shorthair 22
Chihuahua 20
Domestic (unspecified) 19
Terrier - Yorkshire 17
Holstein-Friesian also known as Holstein 17
Shepherd Dog - German 16
Pit Bull 11
Bulldog 11

Associated Drugs

Ivermectin 89
Milbemycin Oxime + Spinosad 83
Spinosad 68
Ceftiofur Crystalline Free Acid 11
Fluralaner Chew Tablets 11
Orbifloxacin 10
Carprofen 9
Afoxolaner 9
Eprinomectin 8
Butorphanol 8
Buprenorphine 8
Dexmedetomidine 8
Pyrantel Pamoate;Sarolaner 8
Trilostane 7
Ceftiofur Hydrochloride 7
Isoflurane 7
Cefovecin 7
Sarolaner 7
Atipamezole 6
Selamectin 6

Temporary blindness Reaction Insights

440 reports name Temporary blindness; 33 recorded a death outcome (7.5% of reported events, not a population-level mortality rate). VeDDRA code: 1829.

By species: Dog (331 reports), Cat (74 reports), Cattle (23 reports). By breed: Retriever - Labrador (29), Crossbred Canine/dog (27), Domestic Shorthair (22).

Most co-reported drugs: Ivermectin (89 reports), Milbemycin Oxime + Spinosad (83 reports), Spinosad (68 reports), Ceftiofur Crystalline Free Acid (11 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.