Reaction profile

The FDA adverse-event record for metastatic neoplasia

215 FDA adverse-event reports reference metastatic neoplasia (VeDDRA 1926). See the species, breeds, and drugs most associated with it below.

215
reports citing this reaction
71.2%
death-coded share
Dog
most-affected species
Oclacitinib Maleate
most-associated drug
Verify with FDA CVM →
215
Total Reports
153
Deaths
71.2%
Death Rate

Species Most Affected

Dog 196
Cat 18
Hedgehog 1

Breeds Most Affected

Retriever - Labrador 24
Retriever - Golden 18
Shepherd Dog - German 18
Crossbred Canine/dog 14
Dog (unknown) 10
Beagle 9
Domestic Shorthair 9
Siberian Husky 5
Bulldog - French 5
Terrier - Bull - American Pit 5

Associated Drugs

Oclacitinib Maleate 42
Milbemycin Oxime + Spinosad 25
Trilostane 22
Carprofen 20
Bedinvetmab 19
Fluralaner Chew Tablets 16
Gabapentin 15
Spinosad 10
Famotidine 10
Grapiprant 10
Prednisone 9
Maropitant Citrate 9
Tigilanol Tiglate 9
Polysulfated Glycosaminoglycan 8
Afoxolaner 7
Diphenhydramine 7
Moxidectin 6
Imidacloprid + Moxidectin 5
Cefovecin 5
Tramadol 5

Metastatic neoplasia Reaction Insights

215 reports name Metastatic neoplasia; 153 recorded a death outcome (71.2% of reported events, not a population-level mortality rate). VeDDRA code: 1926.

By species: Dog (196 reports), Cat (18 reports), Hedgehog (1 reports). By breed: Retriever - Labrador (24), Retriever - Golden (18), Shepherd Dog - German (18).

Most co-reported drugs: Oclacitinib Maleate (42 reports), Milbemycin Oxime + Spinosad (25 reports), Trilostane (22 reports), Carprofen (20 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.