Reaction profile

The FDA adverse-event record for metastatic neoplasia

234 FDA adverse-event reports reference metastatic neoplasia (VeDDRA 1926). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#968 of 2,481
by report volume (all reactions)
234
reports citing this reaction
72.2%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Metastatic neoplasia has 234 reports now versus 227 in that prior snapshot: 7 more (3.1%).

Report change
+7
Death-coded reports
+5
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Metastatic neoplasia changes

FDA AER · VeDDRA plate

Code 1926 VOL-LOW

VOL-LOW · DEATH-HOT · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 234 reports
  • DEATH-HOT 72.2%
  • MID-PACK #968/2481
  • PHOTO-FINISH Brain disorder NOS
  • SPECIES-DOG Dog · 215
  • DRUG-LEAD Oclacitinib Malea… · 42
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Brain disorder NOS (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Report-volume neighbourhood around Metastatic neoplasia

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Lung sound · near235Brain disorder NOS · near234Metastatic neoplasia · this …234Lack of coordination… · near233Local erythema · near233Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Metastatic neoplasia

Metastatic neoplasia: high death-coded share in the FDA AER plate

Signature read: Metastatic neoplasia's 72.2% death-coded share is among the highest in the openFDA reaction corpus. Report volume sits in the middle third of the reaction corpus. Death-coded share is upper-third: 169 of 234 reports (72.2% of named reports). Nearest volume peer: Brain disorder NOS (±0 reports). Lead species Dog (215). Lead co-reported drug Oclacitinib Maleate (42).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 215
Cat 18
Hedgehog 1

Breeds Most Affected

Retriever - Labrador 27
Retriever - Golden 20
Shepherd Dog - German 19
Crossbred Canine/dog 17
Dog (unknown) 10
Beagle 9
Domestic Shorthair 9
Terrier - Bull - American Pit 7
Bulldog - French 6
Dachshund (unspecified) 5

Associated Drugs

Oclacitinib Maleate 42
Bedinvetmab 26
Milbemycin Oxime + Spinosad 25
Trilostane 24
Carprofen 21
Gabapentin 17
Fluralaner Chew Tablets 16
Tigilanol Tiglate 12
Grapiprant 11
Spinosad 10
Prednisone 10
Maropitant Citrate 10
Famotidine 10
Polysulfated Glycosaminoglycan 9
Afoxolaner 8
Moxidectin 7
Diphenhydramine 7
Imidacloprid + Moxidectin 5
Cefovecin 5
Tramadol 5

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Metastatic neoplasia, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar death-coded share

Nearest other reactions by death-coded share (72.2% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Metastatic neoplasia (#968 of 2,481 by report volume); death-coded 72.2%. PlainBreed reaction plate · death-coded share stamp 72.2% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →