Reaction profile

The FDA adverse-event record for chewing - oral cavity disorder (see also 'pruritus')

211 FDA adverse-event reports reference chewing - oral cavity disorder (see also 'pruritus') (VeDDRA 1073). See the species, breeds, and drugs most associated with it below.

211
reports citing this reaction
4.3%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
211
Total Reports
9
Deaths
4.3%
Death Rate

Species Most Affected

Dog 192
Cat 11
Horse 7
Other Bovine 1

Breeds Most Affected

Shepherd Dog - German 16
Retriever - Labrador 12
Chihuahua 12
Crossbred Canine/dog 11
Collie - Border 8
Retriever - Golden 8
Spaniel - Cocker American 7
Terrier (unspecified) 6
Domestic Shorthair 6
Maltese 6

Associated Drugs

Milbemycin Oxime + Spinosad 67
Spinosad 39
Afoxolaner 14
Fluralaner Chew Tablets 12
Ivermectin 8
Ivermectin + Pyrantel As Pamoate Salt 8
Milbemycin Oxime + Praziquantel 8
Oclacitinib Maleate 7
Sarolaner 7
Fipronil 10%/S Methoprene 9% Spot On 5
Cephalexin 5
Distemper Vaccine 4
Rabies Vaccine 4
Selamectin 4
Afoxolaner 2.27% Chewable Tablet (136 Mg) 4
Bordetella Vaccine 3
Ivermectin/Pyrantel Pamoate Chewable 68Mcg/163Mg 3
Ivermectin/Pyrantel Pamoate Chewable 272Mcg/652Mg 3
Carprofen 3
Levothyroxine Sodium 3

Chewing - oral cavity disorder (see also 'Pruritus') Reaction Insights

211 reports name Chewing - oral cavity disorder (see also 'Pruritus'); 9 recorded a death outcome (4.3% of reported events, not a population-level mortality rate). VeDDRA code: 1073.

By species: Dog (192 reports), Cat (11 reports), Horse (7 reports). By breed: Shepherd Dog - German (16), Retriever - Labrador (12), Chihuahua (12).

Most co-reported drugs: Milbemycin Oxime + Spinosad (67 reports), Spinosad (39 reports), Afoxolaner (14 reports), Fluralaner Chew Tablets (12 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.