Reaction profile

The FDA adverse-event record for lack of coordination (see also 'ear' - vestibular disorder)

142 FDA adverse-event reports reference lack of coordination (see also 'ear' - vestibular disorder) (VeDDRA 656). See the species, breeds, and drugs most associated with it below.

142
reports citing this reaction
6.3%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
142
Total Reports
9
Deaths
6.3%
Death Rate

Species Most Affected

Dog 115
Cat 24
Cattle 2
Human 1

Breeds Most Affected

Domestic Shorthair 13
Crossbred Canine/dog 11
Retriever - Labrador 11
Shepherd Dog - Australian 6
Terrier - Yorkshire 5
Shepherd Dog - German 5
Chihuahua 5
Pug 4
Terrier - Jack Russell 4
Dog (unknown) 4

Associated Drugs

Milbemycin Oxime + Spinosad 23
Ivermectin + Pyrantel As Pamoate Salt 12
Afoxolaner 10
Pyrantel Pamoate;Sarolaner 9
Spinosad 8
Carprofen 8
Sarolaner 8
Ivermectin 7
Cefovecin 5
Maropitant Citrate 5
Selamectin 5
Fluralaner 13.64% 12-Week Chew 5
Fluralaner Chew Tablets 4
Nitenpyram 4
Ear Cleaner 4
Anesthetic 3
Isoflurane 3
Milbemycin Oxime 3
Grapiprant 3
Benzoyl Peroxide Shampoo 2

Lack of coordination (see also 'Ear' - vestibular disorder) Reaction Insights

142 reports name Lack of coordination (see also 'Ear' - vestibular disorder); 9 recorded a death outcome (6.3% of reported events, not a population-level mortality rate). VeDDRA code: 656.

By species: Dog (115 reports), Cat (24 reports), Cattle (2 reports). By breed: Domestic Shorthair (13), Crossbred Canine/dog (11), Retriever - Labrador (11).

Most co-reported drugs: Milbemycin Oxime + Spinosad (23 reports), Ivermectin + Pyrantel As Pamoate Salt (12 reports), Afoxolaner (10 reports), Pyrantel Pamoate;Sarolaner (9 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.