Reaction profile

The FDA adverse-event record for glazed eye

1,308 FDA adverse-event reports reference glazed eye (VeDDRA 1211). See the species, breeds, and drugs most associated with it below.

1,308
reports citing this reaction
8.9%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
1,308
Total Reports
116
Deaths
8.9%
Death Rate

Species Most Affected

Dog 1,149
Cat 150
Horse 3
Rabbit 1
Other Birds 1
Cattle 1
Chicken 1
Hamster 1
Goat 1

Breeds Most Affected

Crossbred Canine/dog 86
Retriever - Labrador 79
Domestic Shorthair 70
Chihuahua 66
Terrier - Yorkshire 55
Maltese 51
Boxer (German Boxer) 50
Shih Tzu 43
Retriever - Golden 40
Shepherd Dog - German 34

Associated Drugs

Milbemycin Oxime + Spinosad 372
Afoxolaner 121
Spinosad 114
Ivermectin + Pyrantel As Pamoate Salt 71
Pyrantel Pamoate;Sarolaner 50
Fluralaner Chew Tablets 46
Imidacloprid + Moxidectin 38
Milbemycin Oxime + Praziquantel 36
Carprofen 32
Selamectin 30
Trilostane 30
Fluralaner 13.64% 12-Week Chew 29
Bedinvetmab 27
Lotilaner 25
Ivermectin 22
Spinosad, Milbemycin 22
Sarolaner 22
Moxidectin 20
Buprenorphine 20
Prednisone 19

Glazed eye Reaction Insights

1,308 reports name Glazed eye; 116 recorded a death outcome (8.9% of reported events, not a population-level mortality rate). VeDDRA code: 1211.

By species: Dog (1,149 reports), Cat (150 reports), Horse (3 reports). By breed: Crossbred Canine/dog (86), Retriever - Labrador (79), Domestic Shorthair (70).

Most co-reported drugs: Milbemycin Oxime + Spinosad (372 reports), Afoxolaner (121 reports), Spinosad (114 reports), Ivermectin + Pyrantel As Pamoate Salt (71 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.