Reaction profile

The FDA adverse-event record for underfilling, bottles

1,333 FDA reports name underfilling, bottles, a high-volume reaction in the CVM extract (VeDDRA 99038). Plate stamps and neighbourhood peers follow.

#314 of 2,481
by report volume (all reactions)
1,333
reports citing this reaction
0.0%
death-coded share
Unknown
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Underfilling, Bottles has 1,333 reports now versus 1,321 in that prior snapshot: 12 more (0.9%).

Report change
+12
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Underfilling, Bottles changes

FDA AER · VeDDRA plate

Code 99038 VOL-MID

VOL-MID · DEATH-RARE · UPPER-Q · PHOTO-FINISH · SPECIES-UNKNOWN · DRUG-LEAD · DESK-MID · BOOK-FULL

  • VOL-MID 1,333 reports
  • DEATH-RARE 0.0%
  • UPPER-Q #314/2481
  • PHOTO-FINISH Glazed eye
  • SPECIES-UNKNOWN Unknown · 1,324
  • DRUG-LEAD Praziquantel · 256
  • DESK-MID 6 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Glazed eye (±0 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Underfilling, Bottles

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Alopecia NOS · near1335Liver disorder NOS · near1335INEFFECTIVE, COCCIDIA · near1334Glazed eye · near1333Underfilling, Bottles · this…1333Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Underfilling, Bottles

Underfilling, Bottles: low death-coded share in the FDA AER plate

Signature read: Underfilling, Bottles's 0.0% death-coded share is among the lowest in the openFDA reaction corpus. Report volume is upper-third scale: 1,333 named reports in the openFDA extract. Death-coded share is lower-third: 0 of 1,333 reports (0.0% of named reports). Nearest volume peer: Glazed eye (±0 reports). Lead species Unknown (1,324). Lead co-reported drug Praziquantel (256).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Praziquantel appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Unknown 1,324
Cat 4
Dog 3
Human 2

Breeds Most Affected

Unknown 1,326
Domestic Shorthair 2
Cat (unknown) 2
Dog (unknown) 1
Retriever - Golden 1
Shepherd Dog - Australian 1

Associated Drugs

Praziquantel 256
Oclacitinib Maleate 139
Carprofen 101
Pimobendan 72
Grapiprant 46
Meloxicam 45
Genta/Momet/Clotrim Ear Oint 44
Phenylpropanolamine Hcl 37
Fluoxetine 36
Orbiflox/Momet/Posaco Eardrops 30
Imidacloprid 29
Firocoxib 28
Phenylpropropanolamine Hcl 25
Clindamycin Hydrochloride 18
Cyclosporine 18
Enrofloxacin 17
Hyaluronic Acid 16
Deracoxib 15
Firocoxib 57 Mg Chewable 14
Clomipramine Hydrochloride 14

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Underfilling, Bottles, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (1,333 here).

Similar death-coded share

Nearest other reactions by death-coded share (0.0% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Underfilling, Bottles (#314 of 2,481 by report volume); death-coded 0.0%. PlainBreed reaction plate · death-coded share stamp 0.0% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →