Reaction profile

The FDA adverse-event record for urticarial erythema

77 FDA adverse-event reports reference urticarial erythema (VeDDRA 1859). See the species, breeds, and drugs most associated with it below.

77
reports citing this reaction
2.6%
death-coded share
Dog
most-affected species
Moxidectin
most-associated drug
Verify with FDA CVM →
77
Total Reports
2
Deaths
2.6%
Death Rate

Species Most Affected

Dog 67
Cat 4
Human 4
Pig 1
Donkey 1

Breeds Most Affected

Terrier - Bull - American Pit 11
Boxer (German Boxer) 4
Retriever - Labrador 4
Unknown 4
Chihuahua 4
Domestic Shorthair 3
Terrier - Yorkshire 3
Pit Bull 2
Dog (unknown) 2
Bulldog 2

Associated Drugs

Moxidectin 25
Afoxolaner 10
Fluralaner Chew Tablets 7
Diphenhydramine 6
Milbemycin Oxime + Spinosad 4
Anti-Il31 Mab Mcs Lot #1283563 4
Imidacloprid + Moxidectin 3
Propofol 3
Isoflurane 3
Afoxolaner 136 Mg Chewable Tablets 3
Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str 3
Diphenhydramine Hcl 3
Bordetella Bronchiseptica, Strain 78-9159 3
Dexamethasone 2
Afoxolaner 2.27% Chewable Tablet (68 Mg) 2
Fluids 2
Meloxicam 2
Afoxolaner 68 Mg Chewable Tablets 2
Ivermectin + Pyrantel As Pamoate Salt 2
Milbemycin Oxime + Praziquantel 2

Urticarial erythema Reaction Insights

77 reports name Urticarial erythema; 2 recorded a death outcome (2.6% of reported events, not a population-level mortality rate). VeDDRA code: 1859.

By species: Dog (67 reports), Cat (4 reports), Human (4 reports). By breed: Terrier - Bull - American Pit (11), Boxer (German Boxer) (4), Retriever - Labrador (4).

Most co-reported drugs: Moxidectin (25 reports), Afoxolaner (10 reports), Fluralaner Chew Tablets (7 reports), Diphenhydramine (6 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.