Reaction profile

The FDA adverse-event record for haemolysis

198 FDA adverse-event reports reference haemolysis (VeDDRA 2156). See the species, breeds, and drugs most associated with it below.

198
reports citing this reaction
12.1%
death-coded share
Dog
most-affected species
Trilostane
most-associated drug
Verify with FDA CVM →
198
Total Reports
24
Deaths
12.1%
Death Rate

Species Most Affected

Dog 191
Cat 3
Horse 3
Other Birds 1

Breeds Most Affected

Retriever - Labrador 15
Maltese 13
Shih Tzu 12
Terrier - Yorkshire 10
Terrier - Boston 9
Bichon Frise 9
Chihuahua 9
Beagle 8
Terrier (unspecified) 6
Dachshund - Standard Smooth-haired 6

Associated Drugs

Trilostane 199
Carprofen 15
Desoxycorticosterone Pivalate 13
Prednisone 12
Ursodiol 8
Fluralaner 7
Levothyroxine 6
Rabies Vaccine 5
Tramadol 5
Sarolaner 5
Fluralaner Chew Tablets 4
Milbemycin Oxime + Praziquantel 4
Maropitant Citrate 3
Moxidectin 3
Milbemycin Oxime + Spinosad 3
Meloxicam 3
Clodronate Disodium 3
Gabapentin 3
Sam-E 3
Afoxolaner 3

Haemolysis Reaction Insights

198 reports name Haemolysis; 24 recorded a death outcome (12.1% of reported events, not a population-level mortality rate). VeDDRA code: 2156.

By species: Dog (191 reports), Cat (3 reports), Horse (3 reports). By breed: Retriever - Labrador (15), Maltese (13), Shih Tzu (12).

Most co-reported drugs: Trilostane (199 reports), Carprofen (15 reports), Desoxycorticosterone Pivalate (13 reports), Prednisone (12 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.