Reaction profile

The FDA adverse-event record for haemolysis

198 FDA adverse-event reports reference haemolysis (VeDDRA 2156). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#1044 of 2,481
by report volume (all reactions)
198
reports citing this reaction
12.1%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Haemolysis has 198 reports now versus 198 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Haemolysis changes

FDA AER · VeDDRA plate

Code 2156 VOL-LOW

VOL-LOW · DEATH-ELEV · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 198 reports
  • DEATH-ELEV 12.1%
  • MID-PACK #1044/2481
  • PHOTO-FINISH Drowsiness - systemic…
  • SPECIES-DOG Dog · 191
  • DRUG-LEAD Trilostane · 199
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Drowsiness - systemic disorder (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Report-volume neighbourhood around Haemolysis

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Drowsiness - systemic… · near198Duodenal ulcer · near198Haemolysis · this reaction198INEFFECTIVE, EAR MITES · near198Stomach pain · near198Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Haemolysis

What the FDA AER plate says about Haemolysis

Signature read: report volume at 198 (#1044 of 2,481) is the standout scale stamp on Haemolysis. Report volume sits in the middle third of the reaction corpus. 24 of 198 reports were death-coded (12.1% of named reports, not a population mortality rate). Nearest volume peer: Drowsiness - systemic disorder (±0 reports). Lead species Dog (191). Lead co-reported drug Trilostane (199).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Trilostane appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 191
Cat 3
Horse 3
Other Birds 1

Breeds Most Affected

Retriever - Labrador 15
Maltese 13
Shih Tzu 12
Terrier - Yorkshire 10
Terrier - Boston 9
Bichon Frise 9
Chihuahua 9
Beagle 8
Terrier (unspecified) 6
Dachshund - Standard Smooth-haired 6

Associated Drugs

Trilostane 199
Carprofen 15
Desoxycorticosterone Pivalate 13
Prednisone 12
Ursodiol 8
Fluralaner 7
Levothyroxine 6
Tramadol 5
Rabies Vaccine 5
Sarolaner 5
Fluralaner Chew Tablets 4
Milbemycin Oxime + Praziquantel 4
Maropitant Citrate 3
Moxidectin 3
Milbemycin Oxime + Spinosad 3
Meloxicam 3
Clodronate Disodium 3
Gabapentin 3
Sam-E 3
Grapiprant 3

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Haemolysis, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (198 here).

Similar death-coded share

Nearest other reactions by death-coded share (12.1% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Haemolysis (#1044 of 2,481 by report volume); death-coded 12.1%. PlainBreed reaction plate · report volume stamp 198 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →