Hypoglycaemia

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VeDDRA Code: 1947

3,880 adverse event reports referencing this reaction

3,880
Total Reports
995
Deaths
2560.0%
Death Rate

Species Most Affected

Dog 2,587
Cat 1,270
Horse 10
Ferret 5
Cattle 3
Other 2
Pig 1
Other Canids 1
Human 1

Breeds Most Affected

Domestic Shorthair 711
Crossbred Canine/dog 298
Retriever - Labrador 233
Terrier - Yorkshire 172
Chihuahua 166
Domestic (unspecified) 123
Cat (unknown) 119
Domestic Longhair 114
Shih Tzu 98
Maltese 79

Associated Drugs

Insulin Injectable Vial 844
Bexagliflozin 347
Maropitant Citrate 281
Carprofen 262
Trilostane 194
Protamine Zinc Recombinant Human Insulin 165
Recombinant Human Insulin 158
Milbemycin Oxime + Spinosad 154
Dextrose 121
Human Insulin 115
Insulin 106
Porcine Insulin 103
Afoxolaner 101
Velagliflozin Proline Monohydrate 98
Oclacitinib Maleate 93
Meloxicam 91
Gabapentin 91
Cefovecin 89
Moxidectin 87
Fluralaner Chew Tablets 76

Data Summary

Metric Value
Total reports referencing reaction 3,880
Reports with fatal outcome 995
Case-fatality rate (reported events) 2560.0%
Species observed 9
Breeds observed 20
Drugs associated with reaction 20

Source: FDA Center for Veterinary Medicine — Adverse Event Reporting (CVM AER); reaction term coded under VeDDRA 1947.

Hypoglycaemia Reaction Insights

The FDA Center for Veterinary Medicine database currently lists 3,880 adverse event reports that reference Hypoglycaemia as a reaction term, including 995 reports with a death outcome — a 2560.0% case-fatality figure calculated across only those events where this reaction was coded. The reaction is indexed in the openFDA system under VeDDRA code 1947, the standardized veterinary dictionary used to normalize clinical signs across submitters. Because reports are voluntary and often describe multiple concurrent signs per animal, the volume here reflects reporting intensity rather than true incidence in the broader pet population.

Hypoglycaemia appears most frequently in reports for Dog (2,587 reports), Cat (1,270 reports), Horse (10 reports) — with Dog dominating at 2,587 entries. Within those species, the breeds most often named alongside this reaction are Domestic Shorthair (711), Crossbred Canine/dog (298), Retriever - Labrador (233). These distributions are influenced both by underlying breed popularity and by how veterinarians and owners code a given clinical sign, so they should be interpreted as a reporting fingerprint rather than a pure susceptibility ranking.

The drugs most commonly co-reported with Hypoglycaemia are Insulin Injectable Vial (844 reports), Bexagliflozin (347 reports), Maropitant Citrate (281 reports), Carprofen (262 reports), with Insulin Injectable Vial appearing alongside this reaction in 844 submissions. Co-reporting does not establish that any specific product caused the reaction — FDA CVM data captures temporal association only. The value of these aggregates is in flagging which therapeutic classes appear repeatedly alongside a given clinical sign, so owners and veterinarians can ask targeted questions about medications currently in use.

Source: FDA Center for Veterinary Medicine — Adverse Event Reports FDA Center for Veterinary Medicine — Adverse Event Reports Data reflects voluntary submissions and may not represent actual incidence rates

Related

Data sourced from official AKC, AVMA, ACVO, and breed-club veterinary references. See our methodology for details. Retrieved and formatted by PlainBreed Editorial